High-resolution mapping of in vivo gastrointestinal slow wave activity using flexible printed circuit board electrodes: methodology and validation.
High-resolution mapping of in vivo gastrointestinal slow wave activity using flexible printed circuit board electrodes: methodology and validation.
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DOI：
10.1007/s10439-009-9654-9
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发表时间：
2009-04
影响因子：
3.8
通讯作者：
Cheng, L. K.
中科院分区：
文献类型：
--
作者：
Du, Peng;O'Grady, G.;Egbuji, J. U.;Lammers, W. J.;Budgett, D.;Nielsen, P.;Windsor, J. A.;Pullan, A. J.;Cheng, L. K.
高分辨率、多电极制图为胃肠道慢波活动的起源、传播和异常提供了有价值的新见解。构建高分辨率的测绘阵列以前是一项昂贵且耗时的工作，现有的阵列不太适合人类研究，因为它们不能可靠地反复消毒。介绍了一种适用于GI定位的新型柔性印刷电路板（PCB）多电极阵列的设计和制造，并在猪模型上进行了体内验证。一个改进的方法表征慢波和形成时空激活图显示慢波传播也被证明。验证研究发现，柔性PCB电极阵列能够可靠地记录胃慢波活动，信号质量接近传统环氧树脂嵌入银电极阵列。柔性PCB电极阵列为以前发表的GI慢波活动高分辨率测绘设备提供了临床可行的替代方案。多氯联苯可以低成本批量生产，而且容易消毒，而且可能是一次性的，因此非常适合手术中人类使用。
High-resolution, multi-electrode mapping is providing valuable new insights into the origin, propagation, and abnormalities of gastrointestinal (GI) slow wave activity. Construction of high-resolution mapping arrays has previously been a costly and time-consuming endeavor, and existing arrays are not well suited for human research as they cannot be reliably and repeatedly sterilized. The design and fabrication of a new flexible printed circuit board (PCB) multi-electrode array that is suitable for GI mapping is presented, together with its in vivo validation in a porcine model. A modified methodology for characterizing slow waves and forming spatiotemporal activation maps showing slow waves propagation is also demonstrated. The validation study found that flexible PCB electrode arrays are able to reliably record gastric slow wave activity with signal quality near that achieved by traditional epoxy resin-embedded silver electrode arrays. Flexible PCB electrode arrays provide a clinically viable alternative to previously published devices for the high-resolution mapping of GI slow wave activity. PCBs may be mass-produced at low cost, and are easily sterilized and potentially disposable, making them ideally suited to intra-operative human use.
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