Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background.
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background.
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DOI：
10.1371/journal.pone.0061822
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pfluger PT
中科院分区：
文献类型：
--
作者：
Kirchner H;Heppner KM;Holland J;Kabra D;Tschöp MH;Pfluger PT
Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin has been associated with playing a role in the regulation of glucose homeostasis. However, its precise mechanism and impact on whole glucose metabolism remains to be elucidated. This study aims to clarify the role of the two ghrelin isoforms acyl- and desacyl ghrelin in regulating glucose homeostasis. Therefore ghrelin activating enzyme Ghrelin-O-acyltransferase (GOAT) was ablated in leptin-deficient ob/ob mice to study whether specific acyl ghrelin deficiency or desacyl ghrelin abundance modifies glucose tolerance on a massively obese background. As targeted deletion of acyl ghrelin does not improve glucose homeostasis in our GOAT-ob/ob mouse model we conclude that neither acyl ghrelin nor the increased ratio of desacyl/acyl ghrelin is crucial for controlling glucose homeostasis in the here presented model of massive obesity induced by leptin deficiency.
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影响因子：
82.9
作者：
通讯作者：
--
具有设计的生长素蛋白O-酰基转移酶抑制剂的小鼠中的葡萄糖和体重控制。
DOI：
10.1126/science.1196154
发表时间：
2010-12-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Barnett BP;Hwang Y;Taylor MS;Kirchner H;Pfluger PT;Bernard V;Lin YY;Bowers EM;Mukherjee C;Song WJ;Longo PA;Leahy DJ;Hussain MA;Tschöp MH;Boeke JD;Cole PA
通讯作者：
Cole PA
DOI：
10.1073/pnas.0308604100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Prado, CL;Pugh-Bernard, AE;Sussel, L
通讯作者：
Sussel, L
影响因子：
5.8
作者：
Broglio, F;Benso, A;Ghigo, E
通讯作者：
Ghigo, E
影响因子：
4.1
作者：
Gauna, Carlotta;Delhanty, Patric J. D.;van der Lely, Aart Jan
通讯作者：
van der Lely, Aart Jan