Implementation and validation of a beam-current transformer on a medical pulsed electron beam LINAC for FLASH-RT beam monitoring.

Implementation and validation of a beam-current transformer on a medical pulsed electron beam LINAC for FLASH-RT beam monitoring.
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DOI:
10.1002/acm2.13433
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发表时间:
2021-11
影响因子:
2.1
通讯作者:
Moeckli R
Moeckli R
中科院分区:
医学4区
文献类型:
--
作者:
Oesterle R;Gonçalves Jorge P;Grilj V;Bourhis J;Vozenin MC;Germond JF;Bochud F;Bailat C;Moeckli R

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在脉冲电子束医用直线加速器(LINAC)上实现并验证束电流互感器作为无源监测装置,用于至少3gy的超高剂量率(UHDR)照射,以改进目前用于FLASH放射治疗(FLASH‐RT)研究的剂量学程序。两个束电流互感器(bct)放置在出口的医疗LINAC能够UHDR辐照。通过验证标称值与实测值之间的光束参数一致性,确定测量电荷与吸收剂量之间的关系,以及检查电荷吸收剂量比的短期和长期稳定性,验证了bct作为监测设备的有效性。bct测得的光束参数与标称值吻合。电荷-剂量关系是线性的,与脉冲宽度和频率无关。测量的短期和长期稳定性均在可接受范围内。bct在脉冲电子束医用LINAC上进行了实施和验证,从而改进了当前的剂量测定程序,并允许对光束特性进行更完整的分析。bct被证明是UHDR(因此也是FLASH)实验中光束监测的有效方法。
To implement and validate a beam current transformer as a passive monitoring device on a pulsed electron beam medical linear accelerator (LINAC) for ultra‐high dose rate (UHDR) irradiations in the operational range of at least 3 Gy to improve dosimetric procedures currently in use for FLASH radiotherapy (FLASH‐RT) studies. Two beam current transformers (BCTs) were placed at the exit of a medical LINAC capable of UHDR irradiations. The BCTs were validated as monitoring devices by verifying beam parameters consistency between nominal values and measured values, determining the relationship between the charge measured and the absorbed dose, and checking the short‐ and long‐term stability of the charge‐absorbed dose ratio. The beam parameters measured by the BCTs coincide with the nominal values. The charge‐dose relationship was found to be linear and independent of pulse width and frequency. Short‐ and long‐term stabilities were measured to be within acceptable limits. The BCTs were implemented and validated on a pulsed electron beam medical LINAC, thus improving current dosimetric procedures and allowing for a more complete analysis of beam characteristics. BCTs were shown to be a valid method for beam monitoring for UHDR (and therefore FLASH) experiments.
超高剂量速率闪光照射限制大脑中的反应性神经胶质病。
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