Quantitative measurement of coronary flow during medical revascularization (thrombolysis or angioplasty) in patients with acute infarction.
Quantitative measurement of coronary flow during medical revascularization (thrombolysis or angioplasty) in patients with acute infarction.
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急性梗塞患者进行医疗血运重建（溶栓或血管成形术）期间冠状动脉流量的定量测量。
DOI：
10.1016/s0735-1097(87)80009-8
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发表时间：
1987
影响因子：
24
通讯作者：
Pitt,B
中科院分区：
文献类型：
--
作者：
Nicklas,JM;Diltz,EA;O'Neill,WW;Bourdillon,PD;WaltonJr,JA;Pitt,B
本研究定量评价了急性前壁心肌梗死患者药物血运重建后心肌血流量的变化。采用热稀释法测定了13例急性心肌梗死患者的心大静脉血流变化，其中3例接受了冠状动脉内链激酶治疗，10例接受了经皮腔内血管成形术。左前降支冠状动脉闭塞期间的平均心大静脉流量为62 ± 6 ml/min，动脉再通后增加至70 ± 7 ml/min（p = 0.039）。心大静脉血流量增量存在显著的个体差异，可高度预测7 - 10天时射血分数的变化所表示的功能恢复（r = 0.93，p = 0.0008）。心大静脉血流量增加与残余狭窄程度和缺血持续时间呈负相关（r = 0.88，p = 0.0007）。残余狭窄≤50%的患者的心大静脉血流量增加（14 ± 5 ml/min）显著大于残余狭窄>50%的患者（0 ± 2 ml/min，p = 0.026）。无论是介入治疗前左心室射血分数，血流动力学，也不是年龄预测增量心脏大静脉flow.So，定量测量心脏大静脉流量在药物血运重建急性前壁心肌梗死患者显示可变的复流是生理上显着的。高度残余狭窄和长时间缺血限制了血流的大幅增加，并阻止了功能恢复。本研究强调了这样一个事实，即再通本身不能作为旨在产生心肌再灌注的干预措施成功的指标。
This study quantitatively evaluated the change in myocardial blood flow resulting from medical revascularization in patients with acute anterior myocardial infarction. Changes in great cardiac vein flow were measured using a thermodilution technique in 13 patients with acute infarction; 3 received intracoronary streptokinase and 10 percutaneous transluminal angioplasty. Average great cardiac vein flow during left anterior descending coronary artery occlusion was 62 ± 6 ml/min and increased to 70 ± 7 ml/min (p = 0.039) after arterial recanalization. There was significant individual variability in the great cardiac vein flow increments that was highly predictive of functional recovery as expressed by the change in ejection fraction at 7 to 10 days (r = 0.93, p = 0.0008). Incremental great cardiac vein flow was inversely correlated with the degree of residual stenosis and the duration of ischemia (r = 0.88, p = 0.0007). Patients with residual stenosis ≤50% had a significantly larger increase in great cardiac vein flow (14 ± 5 ml/min) than did those with residual stenosis >50% (0 ± 2 ml/min, p = 0.026). Neither preinterventional left ventricular ejection fraction, hemodynamics nor age predicted incremental great cardiac vein flow.Therefore, quantitative measurements of great cardiac vein flow during medical revascularization in patients with an acute anterior myocardial infarction demonstrate variable reflow that is physiologically significant. A high grade residual stenosis and prolonged period of ischemia limit large increases in flow and prevent functional recovery. This study emphasizes the fact that recanalization in itself cannot be used as an indicator of the success of interventions designed to produce myocardial reperfusion.
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影响因子：
37.8
作者：
RITCHIE, JL;DAVIS, KB;KENNEDY, JW
通讯作者：
KENNEDY, JW
人类短暂冠状动脉闭塞的区域冠状静脉血流反应。
影响因子：
24
作者：
R. Feldman;C. Conti;C. Pepine
通讯作者：
C. Pepine
急性心肌梗死患者溶栓后左心室功能恢复的决定因素
影响因子：
37.8
作者：
Florence H. Sheehan;Detlef G. Mathey;Joachim Schofer;H. Dodge;E. Bolson
通讯作者：
E. Bolson
影响因子：
37.8
作者：
GANZ, W;TAMURA, K;SWAN, HJC
通讯作者：
SWAN, HJC
DOI：
--
发表时间：
1983-04
期刊：
The American journal of pathology
影响因子：
--
作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec
通讯作者：
R. Engler;G. Schmid-Schönbein;R. Pavelec