Immunological considerations and challenges for regenerative cellular therapies.
Immunological considerations and challenges for regenerative cellular therapies.
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DOI：
10.1038/s42003-021-02237-4
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发表时间：
2021-06-25
影响因子：
5.9
通讯作者：
Saeb-Parsy K
中科院分区：
文献类型：
--
作者：
Petrus-Reurer S;Romano M;Howlett S;Jones JL;Lombardi G;Saeb-Parsy K
再生医学的中心目标是用整合并发挥最佳功能的细胞取代受损或患病的组织。多能干细胞产生无限数量分化细胞的能力具有相当大的治疗兴趣，几项临床试验正在进行中。然而，宿主的免疫反应是临床翻译的重要障碍。在这里，我们描述了宿主先天免疫反应和获得性免疫反应作为同种异体移植排斥反应的触发因素的作用。我们讨论了细胞疗法是如何决定免疫反应的。此外，我们描述了可用于检测细胞治疗的免疫原性的体外和体内实验方法的范围，最后我们回顾了改善免疫排斥反应的潜在策略。总之，我们主张建立平台，汇聚多学科的专业知识和基础设施，以全面研究细胞疗法的免疫原性，以确保其临床安全性和有效性。在这篇综述中，Petrus-Reurer等人描述了先天性免疫反应和获得性免疫反应在同种异体移植排斥反应中的作用，并讨论了这些反应是如何由感兴趣的细胞疗法决定的。它们还描述了用于检查细胞疗法的免疫原性的体外和体内方法的范围，并考虑了可用于改善免疫排斥反应的潜在混杂因素和策略。
The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that integrate and function optimally. The capacity of pluripotent stem cells to produce unlimited numbers of differentiated cells is of considerable therapeutic interest, with several clinical trials underway. However, the host immune response represents an important barrier to clinical translation. Here we describe the role of the host innate and adaptive immune responses as triggers of allogeneic graft rejection. We discuss how the immune response is determined by the cellular therapy. Additionally, we describe the range of available in vitro and in vivo experimental approaches to examine the immunogenicity of cellular therapies, and finally we review potential strategies to ameliorate immune rejection. In conclusion, we advocate establishment of platforms that bring together the multidisciplinary expertise and infrastructure necessary to comprehensively investigate the immunogenicity of cellular therapies to ensure their clinical safety and efficacy. In this Review, Petrus-Reurer et al describe the roles of both innate and adaptive immune responses in allogeneic graft rejection, in addition to discuss how such responses are determined by the cellular therapy of interest. They also describe the range of in vitro and in vivo approaches used to examine the immunogenicity of cellular therapies and consider potential confounders and strategies that can be employed to ameliorate immune rejection.
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iPSC 衍生的调节性树突细胞通过生成同种异体抗原特异性调节性 T 细胞来抑制同种异体移植排斥
影响因子：
5.9
作者：
Cai S;Hou J;Fujino M;Zhang Q;Ichimaru N;Takahara S;Araki R;Lu L;Chen JM;Zhuang J;Zhu P;Li XK
通讯作者：
Li XK
T细胞共刺激和共抑制的分子机制。
DOI：
10.1038/nri3405
发表时间：
2013-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.2
作者：
Boyd AS;Wood KJ
通讯作者：
Wood KJ
影响因子：
5.2
作者：
Brunlid, Gabriella;Pruszak, Jan;Sonntag, Kai-Christian
通讯作者：
Sonntag, Kai-Christian
影响因子：
5.2
作者：
Brimble, Sandii N.;Sherrer, Eric S.;Schulz, Thomas C.
通讯作者：
Schulz, Thomas C.