Red blood cell membrane concentration of cis-palmitoleic and cis-vaccenic acids and risk of coronary heart disease.
Red blood cell membrane concentration of cis-palmitoleic and cis-vaccenic acids and risk of coronary heart disease.
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DOI：
10.1016/j.amjcard.2012.04.027
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发表时间：
2012-08-15
期刊：
影响因子：
--
通讯作者：
Gaziano JM
中科院分区：
文献类型：
--
作者：
Djoussé L;Matthan NR;Lichtenstein AH;Gaziano JM
Although previous studies have suggested associations between plasma palmitoleic acid and coronary heart disease (CHD) risk factors including blood pressure, inflammation, and insulin resistance, little is known about the relation of palmitoleic acid with CHD. This ancillary study of the Physicians’ Health Study was designed to examine whether red blood cell (RBC) membrane cis-palmitoleic acid and cis-vaccenic acid – two fatty acids that can be synthesized endogenously – are associated with CHD risk. We used a risk set sampling method to prospectively select 1000 incident CHD events and 1000 matched controls. RBC membrane fatty acids were measured using gas chromatography. CHD cases were ascertained using annual follow-up questionnaire and validated by an Endpoint Committee through review of medical records. In a conditional logistic regression adjusting for demographics, anthropometric, lifestyle factors, and comorbidity, odds ratios (95% CI) for CHD were 1.0 (ref), 1.29 (0.95–1.75), 1.08 (0.78–1.51), 1.25 (0.90–1.75), and 1.48 (1.03–2.14) across consecutive quintiles of RBC membrane cis- palmitoleic acid (p for trend 0.041). Odds ratio associated with each standard deviation higher RBC membrane cis- palmitoleic acid was 1.19 (95% CI: 1.06–1.35) in a multivariable adjusted model. Lastly, RBC membrane cis-vaccenic acid was inversely associated with CHD risk [OR: 0.79 (95% CI: 0.69–0.91) per standard deviation increase]. In conclusion, our data showed a positive association between RBC membrane cis-palmitoleic acid and CHD risk in male physicians. Furthermore, RBC membrane cis-vaccenic acid was inversely related to CHD.
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影响因子：
9.8
作者：
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Siscovick, David S.
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通讯作者：
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通讯作者：
Hotamisligil, Gokhan S.
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作者：
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通讯作者：
HENNEKENS, CH