Recognition of specific targets by cultured dorsal root ganglion neurons

Recognition of specific targets by cultured dorsal root ganglion neurons
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培养的背根神经节神经元对特定目标的识别

DOI:
10.1523/jneurosci.07-08-02305.1987
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发表时间:
1987
影响因子:
--
通讯作者:
M. Fishman
M. Fishman
中科院分区:
生物学2区
文献类型:
--
作者:
L. Baizer;M. Fishman

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相似文献

我们已经评估了不同的目标细胞群对轴突转运蛋白的影响,通过使用室室细胞培养系统,将大鼠感觉神经元的体细胞与生长的轴突分开。当生长的轴突接触脊髓细胞(这是正常的体内靶标)时,3种快速运输蛋白的标记减少,并且不受成纤维细胞或心脏细胞接触的影响。由脊髓细胞调节的培养基不起这种作用。因此,在体外,特定种类的细胞可以被感觉神经元区分为靶组织。这种识别伴随着轴突运输蛋白的特定分子变化。
We have assessed the effects of different target cell populations on axonally transported proteins by the use of compartmental cell culture systems that separate the soma from the growing axons of rat sensory neurons. The labeling of 3 rapidly transported proteins diminishes when the growing axon contacts spinal cord cells (which are normal in vivo targets), and remains unaffected by contact with fibroblasts or heart cells. Medium conditioned by spinal cord cells does not exert this effect. Thus, specific classes of cells may be distinguished as target tissue by sensory neurons in vitro. Such recognition is accompanied by specific molecular changes in axonally transported proteins.
新的神经元生长因子。
DOI: 10.1146/annurev.ne.07.030184.001053
发表时间: 1984
影响因子: 13.9
作者:
Berg,DK
通讯作者: Berg,DK
DOI: 10.1126/science.6474175
发表时间: 1984-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者: STANFIELD, BB