Targeted Memory Reactivation during Sleep Adaptively Promotes the Strengthening or Weakening of Overlapping Memories
Targeted Memory Reactivation during Sleep Adaptively Promotes the Strengthening or Weakening of Overlapping Memories
复制标题
睡眠期间有针对性的记忆重新激活适应性地促进重叠记忆的加强或减弱
DOI：
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发表时间：
2017
影响因子：
5.3
通讯作者：
L. Fuentemilla
中科院分区：
文献类型：
--
作者：
Javiera P. Oyarzún;J. Morís;David Luque;R. de Diego;L. Fuentemilla
系统记忆巩固被概念化为一个主动过程，即新编码的记忆表征通过睡眠期间的选择性记忆再激活而得到加强。然而，我们的学习经历在内容上是高度重叠的（即共享共同的元素），这些事件的记忆被组织在重叠相关事件的复杂网络中。睡眠期间的选择性记忆再激活是否以及如何影响这些在清醒时获得的重叠记忆还有待探索。在这里，我们在一组成年女性和男性中测试了这样一种预测，即睡眠期间选择性记忆的重新激活需要相关事件的重新激活，这可能导致大脑根据这些相关记忆与共享元素的相对关联强度，自适应地调节这些相关记忆是加强还是从记忆网络中删除。我们的研究结果表明，存在有效的调节神经机制，可以控制睡眠期间复杂记忆网络的形成，作为联想记忆强度的函数。大量研究表明，系统记忆巩固是一个主动的、选择性的、睡眠依赖的过程，在这个过程中，只有新记忆的子集通过它们的再激活而稳定下来。然而，学习经历在内容上是高度重叠的，因此事件被编码在一个复杂的相关记忆网络中。记忆再激活是否以及如何影响在清醒时获得的重叠记忆还有待探索。在这里，我们表明，睡眠记忆再激活促进重叠记忆的增强和减弱是基于它们的联想记忆强度。这些结果表明，存在一种有效的调节神经机制，避免了多事件记忆表征的杂乱形成，促进了复杂记忆网络的稳定。
System memory consolidation is conceptualized as an active process whereby newly encoded memory representations are strengthened through selective memory reactivation during sleep. However, our learning experience is highly overlapping in content (i.e., shares common elements), and memories of these events are organized in an intricate network of overlapping associated events. It remains to be explored whether and how selective memory reactivation during sleep has an impact on these overlapping memories acquired during awake time. Here, we test in a group of adult women and men the prediction that selective memory reactivation during sleep entails the reactivation of associated events and that this may lead the brain to adaptively regulate whether these associated memories are strengthened or pruned from memory networks on the basis of their relative associative strength with the shared element. Our findings demonstrate the existence of efficient regulatory neural mechanisms governing how complex memory networks are shaped during sleep as a function of their associative memory strength. SIGNIFICANCE STATEMENT Numerous studies have demonstrated that system memory consolidation is an active, selective, and sleep-dependent process in which only subsets of new memories become stabilized through their reactivation. However, the learning experience is highly overlapping in content and thus events are encoded in an intricate network of related memories. It remains to be explored whether and how memory reactivation has an impact on overlapping memories acquired during awake time. Here, we show that sleep memory reactivation promotes strengthening and weakening of overlapping memories based on their associative memory strength. These results suggest the existence of an efficient regulatory neural mechanism that avoids the formation of cluttered memory representation of multiple events and promotes stabilization of complex memory networks.
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影响因子：
16.2
作者：
Ngo, Hong-Viet V.;Martinetz, Thomas;Moelle, Matthias
通讯作者：
Moelle, Matthias
DOI：
10.1037//0278-7393.18.4.691
发表时间：
1992-07
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
F. Haist;A. Shimamura;Larry R. Squire
通讯作者：
F. Haist;A. Shimamura;Larry R. Squire
影响因子：
3.7
作者：
Newman, Ehren L.;Norman, Kenneth A.
通讯作者：
Norman, Kenneth A.
影响因子：
5.6
作者：
Riedner, Brady A.;Vyazovskiy, Vladyslav V.;Tononi, Giulio
通讯作者：
Tononi, Giulio