Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome.
Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome.
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ANGPTL4基因SNP Rs1044250与体重管理之间的串扰是代谢综合征的危险因素
DOI：
10.1186/s12967-021-02739-z
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发表时间：
2021-02-16
影响因子：
7.4
通讯作者：
Wang Z
中科院分区：
文献类型：
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作者：
Tong Z;Peng J;Lan H;Sai W;Li Y;Xie J;Tan Y;Zhang W;Zhong M;Wang Z
背景代谢综合征（Mets）的患病率与心血管事件的发生率增加密切相关。血管生成素样蛋白4（Angiopoietin-like protein 4，ANGPTL 4）参与脂质代谢的调节，可为Mets的基因治疗提供靶点。本研究旨在探讨ANGPTL 4基因单核苷酸多态性（SNP）rs 1044250与Mets发病的关系，以及SNP rs 1044250与Mets.MethodsWe招募了1018例Mets病例和1029例对照。采集血样进行SNP rs 1044250基因分型，收集基线信息和Mets相关指标。结果ANGPTL 4基因单核苷酸多态性rs 1044250是腰围增加的独立危险因素（OR 1.618，95% CI [1.119-2.340];p= 0.011）、血压升高（OR 1.323，95% CI [1.002-1.747];p= 0.048）和Mets（OR 1.875，95% CI [1.363-2.580];p< 0.001）。随访调查显示，rs 1044250 CC基因型患者体重增加的Mets组分数量增加（M [Q1，Q3]：CC 1（0，1），CT + TT 0 [-1，1];p= 0.021）; SNP rs 1044250和体重管理之间的相互作用是收缩压升高的危险因素（β = 0.075，P < 0.001）和舒张压升高（β = 0.097，p < 0.001），体重管理和SNP rs 1044250的协同效应为负（S < 1）。结论ANGPTL 4基因多态性rs 1044250是Mets腰围增加和血压升高的独立危险因素，因此，对Mets而言，ANGPTL 4基因多态性rs 1044250是Mets腰围增加和血压升高的独立危险因素。然而，当体重增加时，野生型SNP 1044250的患者更有可能患有Mets，这主要是由于血压升高。
BackgroundThe prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This observational case control study was designed to elucidate the relationship betweenANGPTL4gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the interaction between SNP rs1044250 and weight management on Mets.MethodsWe have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was genotyped with blood samples, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle interventions and changes in Mets-related indicators.ResultsANGPTL4gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119–2.340];p= 0.011), elevated blood pressure (OR 1.323, 95% CI [1.002–1.747];p= 0.048), and Mets (OR 1.875, 95% CI [1.363–2.580];p< 0.001). The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [− 1, 1];p= 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased systolic blood pressure (β = 0.075,p< 0.001) and increased diastolic blood pressure (β = 0.097,p< 0.001), the synergistic effect of weight management and SNP rs1044250 is negative (S < 1).ConclusionANGPTL4gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. However, patients with wild type SNP 1044250 are more likely to have Mets when the body weight is increased, mainly due to elevated blood pressure.
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影响因子：
2.2
作者：
Bailetti, D.;Bertoccini, L.;Baroni, M. G.
通讯作者：
Baroni, M. G.
DOI：
10.1161/circgenetics.111.961482
发表时间：
2012-04-01
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Kristiansson K;Perola M;Tikkanen E;Kettunen J;Surakka I;Havulinna AS;Stancáková A;Barnes C;Widen E;Kajantie E;Eriksson JG;Viikari J;Kähönen M;Lehtimäki T;Raitakari OT;Hartikainen AL;Ruokonen A;Pouta A;Jula A;Kangas AJ;Soininen P;Ala-Korpela M;Männistö S;Jousilahti P;Bonnycastle LL;Järvelin MR;Kuusisto J;Collins FS;Laakso M;Hurles ME;Palotie A;Peltonen L;Ripatti S;Salomaa V
通讯作者：
Salomaa V
影响因子：
8.2
作者：
Janssen AWF;Katiraei S;Bartosinska B;Eberhard D;Willems van Dijk K;Kersten S
通讯作者：
Kersten S
影响因子：
4.5
作者：
Abu-Farha M;Cherian P;Qaddoumi MG;AlKhairi I;Sriraman D;Alanbaei M;Abubaker J
通讯作者：
Abubaker J
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.