Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application.
Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application.
复制标题
用于脂质纳米微系统的先进微流控技术：从合成到生物应用
DOI：
10.3390/pharmaceutics14010141
复制
发表时间：
2022-01-07
期刊：
影响因子：
5.4
通讯作者：
de la Torre LG
中科院分区：
文献类型：
--
作者：
Carvalho BG;Ceccato BT;Michelon M;Han SW;de la Torre LG
微流体技术是一种新兴的技术，可以作为一个强大的工具，用于设计脂质纳米-微米结构的生物应用。这些脂质结构可用作各种药物和遗传物质的载体。微流控技术还允许设计可持续的工艺，减少资金需求，同时可以使用并行化来扩大规模以提高产量。从这个角度出发，本文综述了近年来通过微流体技术合成基于脂质的纳米结构（脂质体、脂质复合物、脂质纳米颗粒、核壳纳米颗粒和仿生纳米囊泡）的研究进展。此外，本文还介绍了近年来利用微流控技术制备脂质微结构的研究进展。还描述了使用微凝胶和基于液滴的微流体控制释放脂质有效载荷的新策略。为了解决脂质纳米颗粒筛选的微流体的重要性，微流体系统如何可以用来模拟细胞环境的概述。本文还讨论了设计新型纳米和微米尺度的未来趋势和前景。
Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein.
登录
查看更多内容
影响因子：
7.4
作者：
Abe, Koji;Suzuki, Koji;Citterio, Daniel
通讯作者：
Citterio, Daniel
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
5.4
作者：
Aldosari BN;Alfagih IM;Almurshedi AS
通讯作者：
Almurshedi AS
影响因子：
8
作者：
Bozzuto G;Molinari A
通讯作者：
Molinari A
影响因子：
5.6
作者：
BANGHAM, AD;STANDISH, MM;WATKINS, JC
通讯作者：
WATKINS, JC