Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson's disease.
Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson's disease.
复制标题
额顶叶网络弹性与帕金森病认知能力下降的保护有关。
DOI：
10.1038/s42003-021-02478-3
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发表时间：
2021-09-01
影响因子：
5.9
通讯作者：
Dayan E
中科院分区：
文献类型：
--
作者：
Cascone AD;Langella S;Sklerov M;Dayan E
虽然帕金森氏症最初被定义为一种运动障碍，但它也以一系列非运动症状为特征，包括认知能力下降。帕金森氏病患者认知能力下降的发生和发展是多种多样的，而导致或预防帕金森氏病认知能力下降的神经生物学机制尚不清楚。本研究利用帕金森病认知功能减退患者和非帕金森病患者的静息状态功能磁共振成像数据，研究了帕金森氏病患者的脑网络拓扑弹性与认知功能之间的关系。通过利用网络攻击分析，我们证明了相对于经历认知衰退的帕金森病患者，认知稳定的帕金森病患者的额顶网络对网络扰动的弹性明显更强。我们的发现表明，额顶神经网络的拓扑健壮性与帕金森氏症患者没有认知能力下降有关。Arianna Cascon等人。研究帕金森病(PD)患者额顶顶叶大脑网络弹性与认知功能下降之间的关系。他们的结果表明，与认知正常的帕金森病患者和健康的非帕金森病患者相比，帕金森病患者和认知功能减退的人对额顶网络的网络攻击或干扰的耐受性降低。
Though Parkinson’s disease is primarily defined as a movement disorder, it is also characterized by a range of non-motor symptoms, including cognitive decline. The onset and progression of cognitive decline in individuals with Parkinson’s disease is variable, and the neurobiological mechanisms that contribute to, or protect against, cognitive decline in Parkinson’s disease are poorly understood. Using resting-state functional magnetic resonance imaging data collected from individuals with Parkinson’s disease with and without cognitive decline, we examined the relationship between topological brain-network resilience and cognition in Parkinson’s disease. By leveraging network attack analyses, we demonstrate that relative to individuals with Parkinson’s disease experiencing cognitive decline, the frontoparietal network in cognitively stable individuals with Parkinson’s disease is significantly more resilient to network perturbation. Our findings suggest that the topological robustness of the frontoparietal network is associated with the absence of cognitive decline in individuals with Parkinson’s disease. Arianna Cascone et al. examine the relationship between frontoparietal brain network resilience and cognitive decline in Parkinson’s disease (PD). Their results suggest that individuals with PD and cognitive decline exhibit reduced tolerance to network "attacks" or perturbation in the frontoparietal network, compared to both individuals with PD with normal cognition and healthy, non-PD controls.
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