Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort.
Reverters from PD-MCI to cognitively intact are at risk for future cognitive impairment: Analysis of the PPMI cohort.
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DOI：
10.1016/j.parkreldis.2017.12.006
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发表时间：
2018-03
影响因子：
4.1
通讯作者：
Szymkowicz SM
中科院分区：
文献类型：
--
作者：
Jones JD;Kuhn TP;Szymkowicz SM
过去的研究表明，帕金森氏病(PD)和轻度认知障碍(MCI)患者中的很大一部分人未来将恢复到认知完整(CI)状态。老龄化研究表明，从MCI恢复到CI的个人在未来重新转换为MCI或痴呆症的风险更高。目前的研究调查了从PD轻度认知障碍(PD-MCI)恢复到CI的个体是否会增加未来患PD-MCI和帕金森氏病痴呆(PDD)的风险。这项研究利用了帕金森进展标志物倡议(PPMI)的数据。样本包括364名新诊断的帕金森病患者，他们每年进行长达4年的跟踪调查。在第一次和第二次评估的基础上，我们确定了在每次评估中属于CI(CI稳定)的个体，以及在基线时属于PDMCI但随后恢复到CI(恢复)的个体。分析检查了回归组的参与者在未来的评估中是否比CI稳定组的参与者面临更大的认知障碍风险。与CI稳定组相比，在第2、3和第4年的随访中，返回组的参与者未来认知损害(PD-MCI或PDD)的风险更大。在调整了年龄、性别、教育程度、抑郁症状和运动严重程度后，复退组未来认知损害的风险继续增加。很大比例的PD-MCI患者在一年内不会表现出认知障碍的证据。然而，这些“反转者”继续面临认知障碍未来发展的风险。
Past studies have shown that a large portion of individuals with Parkinson’s disease (PD) and mild cognitive impairment (MCI) will revert to a cognitively intact (CI) status in the future. Aging studies have shown that individuals who revert from MCI to CI are at increased risk for reconverting to MCI or dementia in the future. The current study examined if individuals who revert from PD-mild cognitive impairment (PD-MCI) to CI will be at increased risk for future PD-MCI and Parkinson’s disease dementia (PDD). The study utilized data from the Parkinson’s Progression Markers Initiative (PPMI). The sample included 364 newly diagnosed PD participants who were followed annually for up to 4 years. Based on the first and second assessments, we identified individuals who were CI at each assessment (CI-Stable) and individuals who were PDMCI at baseline but then reverted to CI (Reversion). Analyses examined if participants in the Reversion group were at greater risk, relative to the CI-Stable group, for cognitive impairment at future assessments. Participants in the Reversion group were at greater risk for future cognitive impairment (PD-MCI or PDD) at the 2nd, 3rd and 4th annual follow-up, relative to the CI-Stable group. The Reversion group continued to be at increased risk for future cognitive impairment when adjusting for age, gender, education, depressive symptoms, and motor severity. A large proportion of individuals with PD-MCI will not show evidence of cognitive impairment within a year. However, these “reverters” continue to be at risk for future development of cognitive impairment.
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影响因子：
3.7
作者：
Kueider AM;Parisi JM;Gross AL;Rebok GW
通讯作者：
Rebok GW
影响因子：
2.4
作者：
Jones, Jacob D.;Marsiske, Michael;Okun, Michael S.;Bowers, Dawn
通讯作者：
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DOI：
10.1176/appi.neuropsych.15090221
发表时间：
2016-06-01
影响因子：
2.9
作者：
Jones, Jacob D.;Mangal, Paul;Bowers, Dawn
通讯作者：
Bowers, Dawn
影响因子：
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作者：
Dalrymple-Alford, J. C.;MacAskill, M. R.;Anderson, T. J.
通讯作者：
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影响因子：
9.9
作者：
Roberts, Rosebud O.;Knopman, David S.;Petersen, Ronald C.
通讯作者：
Petersen, Ronald C.