The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs.
The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs.
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DOI：
10.1590/s1807-59322008000500014
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
E EE
中科院分区：
文献类型：
--
作者：
Ozenoglu A;Balci H;Ugurlu S;Caglar E;Uzun H;Sarkis C;Gunay C;E EE
本研究的目的是调查血清瘦素，脂联素和对氧磷酶1水平的成年女性接受药物治疗的各种精神疾病。研究组由32名肥胖女性组成（平均年龄40.53 ± 11.00岁，平均体重指数35.44 ± 5.33 kg/m2），接受精神疾病治疗，对照组包括22名肥胖女性（平均年龄35.95 ± 9.16岁，平均体重指数30.78 ± 3.33 kg/m2），无精神疾病。使用生物电阻抗装置进行分析。采集空腹血样进行全血细胞计数和各种生化检查，包括测定瘦素、脂联素和对氧磷酶1活性。体重指数、腰围和臀围、体脂百分比、空腹血糖、胰岛素、糖化血红蛋白、胰岛素抵抗的稳态模型评估、丙氨酸转氨酶、天冬氨酸转氨酶和瘦素水平在研究组中显著高于对照组。虽然两组的体重与瘦素水平呈正相关，但对照组的体重与脂联素水平呈负相关，研究组的体重与脂联素水平呈正相关。在研究组中，体重指数和臀围与瘦素水平呈正相关，臀围与脂联素水平呈正相关，腰臀比与对氧磷酶水平呈正相关。在对照组中，体重指数以及腰围和臀围与瘦素水平呈正相关。体重、体重指数和臀围也与对照组的脂联素/瘦素比值呈负相关。这项研究表明，接受精神药物治疗的患者患肥胖相关疾病的风险更高，特别是代谢综合征、糖尿病和心血管疾病。
The aim of this study was to investigate serum leptin, adiponectin and paraoxonase1 levels in adult females receiving pharmacotherapy for various psychiatric disorders. The study group consisted of 32 obese females (mean age 40.53 ± 11.00 years, mean body mass index 35.44 ± 5.33 kg/m2) who were receiving treatment for psychiatric disorders, and the control group included 22 obese females (mean age 35.95 ± 9.16 years, mean body mass index 30.78 ± 3.33 kg/m2) who were free of psychiatric disorders. Analyses were performed using a bioelectrical impedance device. Fasting blood samples were obtained for complete blood count and various biochemical tests, including determination of leptin, adiponectin and paraoxonase1 activity. Body mass index, waist and hip circumference, body fat percentage, fasting blood glucose, insulin, glycosylated hemoglobin, homeostasis model assesment of insulin resistance, alanine transaminase, aspartate tarnsaminase, and leptin levels were significantly higher in the study group than in controls. Although body weight was positively correlated with leptin levels in both groups, body weight was negatively correlated with adiponectin levels in the control group and positively correlated with adiponectin levels in the study group. In the study group, body mass index and hip circumference correlated positively with leptin levels, hip circumference correlated positively with adiponectin levels, and waist to hip ratio correlated positively with paraoxonase levels. In the control group, body mass index as well as waist and hip circumferences were positively correlated with leptin levels. Weight, body mass index, and hip circumference were also negatively correlated with the adiponectin/leptin ratio in the control group. This study indicates a higher risk for obesity-related disorders, particularly metabolic syndrome, diabetes and cardiovascular disease, in patients treated with psychiatric drugs.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
2.5
作者：
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Sorbi, Sandro