Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
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DOI：
10.1155/2020/7948095
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发表时间：
2020
影响因子：
4.6
通讯作者：
Peng QL
中科院分区：
文献类型：
--
作者：
Shen YW;Zhang YM;Huang ZG;Wang GC;Peng QL
可溶性CD206(SCD206)被认为是巨噬细胞激活的标志物，先前的研究证明它是预测抗黑色素瘤分化相关基因5-(抗-MDA-5-)阳性皮肌炎(DM)相关性间质性肺疾病(ILD)严重程度的潜在生物标志物。为探讨sCD206在DM各亚型中的作用，我们检测了除抗MDA-5抗体外，其他肌炎特异性自身抗体阳性患者的血清sCD206水平，并阐明其临床意义。用国产酶联免疫吸附试验试剂盒检测了150例糖尿病患者和52例健康人血清sCD206的浓度。分析sCD206水平与临床表现、实验室检查及肺功能检测指标的相关性。糖尿病患者血清sCD206浓度中位数显著高于肥厚型糖尿病患者(p<；0.0001)。此外，中位数sCD206水平在ILD患者中升高(p=0.001)，尤其是在那些快速进展的ILD患者(p<；0.0001)。此外，sCD206水平与肺功能试验结果呈负相关，包括预计用力肺活量百分比(r=−0.234，p=0.023)、预计1秒用力呼气量百分比(r=−0.225，p=0.030)和预计一氧化碳弥散量百分比(r=−0.261，p=0.014)。经年龄和性别调整的多变量分析显示，sCD206是糖尿病患者RP-ILD的独立预后因素。纵向研究显示，sCD206水平与医生视觉模拟评定量表评分呈正相关(β=54.201，p=0.001)。血清sCD206水平在DM患者中显著升高，并与RP-ILD显著相关，提示sCD206是DM患者RP-ILD的重要生物学预测因子。
Soluble CD206 (sCD206) is considered a macrophage activation marker, and a previous study proved it as a potential biomarker to predict the severity of anti-melanoma differentiation-associated gene 5- (anti-MDA-5-) positive dermatomyositis- (DM-) associated interstitial lung disease (ILD). To investigate the role of sCD206 in various subtypes of DM, we evaluated the serum level of sCD206 in patients with different myositis-specific autoantibodies besides anti-MDA-5 and clarified its clinical significance. Commercial enzyme-linked immunosorbent assay kits were used to detect serum concentrations of sCD206 in 150 patients with DM and 52 healthy controls (HCs). Correlations between sCD206 levels and clinical features, laboratory examinations, and pulmonary function test parameters were analysed. The median concentrations of serum sCD206 in DM patients were significantly higher than those in HCs (p < 0.0001). Furthermore, median sCD206 levels were elevated in patients with ILD (p = 0.001), especially in those with rapidly progressive ILD (RP-ILD) (p < 0.0001). In addition, sCD206 levels were negatively correlated with the pulmonary function test results, including the percent predicted forced vital capacity (r = −0.234, p = 0.023), percent predicted forced expiratory volume in one second (r = −0.225, p = 0.030), and percent predicted carbon monoxide diffusion capacity (r = −0.261, p = 0.014). Age- and gender-adjusted multivariable analysis showed that sCD206 was an independent prognostic factor for RP-ILD in patients with DM. A longitudinal study showed that sCD206 levels were positively correlated with the physician global assessment visual analog scale scores (β = 54.201, p = 0.001). Serum sCD206 levels were significantly increased in patients with DM and significantly associated with RP-ILD, suggesting that sCD206 is an important biological predictor of RP-ILD in patients with DM.
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影响因子：
4.9
作者：
Enomoto Y;Suzuki Y;Hozumi H;Mori K;Kono M;Karayama M;Furuhashi K;Fujisawa T;Enomoto N;Nakamura Y;Inui N;Suzuki D;Ogawa N;Nakashima R;Mimori T;Iwashita T;Suda T
通讯作者：
Suda T
影响因子：
9.6
作者：
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通讯作者：
Danoff, Sonye K.
影响因子：
5.5
作者：
Isenberg, DA;Allen, E;Miller, F
通讯作者：
Miller, F
影响因子：
27.4
作者：
Lundberg IE;Tjärnlund A;Bottai M;Werth VP;Pilkington C;Visser M;Alfredsson L;Amato AA;Barohn RJ;Liang MH;Singh JA;Aggarwal R;Arnardottir S;Chinoy H;Cooper RG;Dankó K;Dimachkie MM;Feldman BM;Torre IG;Gordon P;Hayashi T;Katz JD;Kohsaka H;Lachenbruch PA;Lang BA;Li Y;Oddis CV;Olesinska M;Reed AM;Rutkowska-Sak L;Sanner H;Selva-O'Callaghan A;Song YW;Vencovsky J;Ytterberg SR;Miller FW;Rider LG;International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland)
通讯作者：
International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland)
影响因子：
5.4
作者：
Martinez-Pomares, L;Wienke, D;Gordon, S
通讯作者：
Gordon, S