Male infertility and its causes in human.
Male infertility and its causes in human.
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DOI：
10.1155/2012/384520
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发表时间：
2012
影响因子：
1.4
通讯作者：
Sengoku K
中科院分区：
文献类型：
--
作者：
Miyamoto T;Tsujimura A;Miyagawa Y;Koh E;Namiki M;Sengoku K
不孕症是发达国家面临的最严重的社会问题之一。一般来说，大约一半的不孕症病例是由与男性伴侣有关的因素引起的。迄今为止，已经开发了各种治疗男性不育症的方法，并正在稳步产生效果。然而，对于睾丸中缺乏成熟精子的非梗阻性无精子症患者没有有效的治疗方法。虽然有证据表明，许多男性不育患者有遗传倾向的条件，原因还没有阐明在绝大多数情况下。本文讨论了被认为可能与男性不育有关的环境因素，以及已明确显示与人类男性不育有关的基因，包括我们最近的发现。
Infertility is one of the most serious social problems facing advanced nations. In general, approximate half of all cases of infertility are caused by factors related to the male partner. To date, various treatments have been developed for male infertility and are steadily producing results. However, there is no effective treatment for patients with nonobstructive azoospermia, in which there is an absence of mature sperm in the testes. Although evidence suggests that many patients with male infertility have a genetic predisposition to the condition, the cause has not been elucidated in the vast majority of cases. This paper discusses the environmental factors considered likely to be involved in male infertility and the genes that have been clearly shown to be involved in male infertility in humans, including our recent findings.
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影响因子：
9.8
作者：
Dam, Anika H. D. M.;Koscinski, Isabelle;Viville, Stephane
通讯作者：
Viville, Stephane
影响因子：
6.1
作者：
Jorgensen, N;Andersen, AG;Skakkebæk, NE
通讯作者：
Skakkebæk, NE
影响因子：
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作者：
Kenkel, S;Rolf, C;Nieschlag, E
通讯作者：
Nieschlag, E
影响因子：
158.5
作者：
LEVINE, RJ;MATHEW, RM;WORKING, PK
通讯作者：
WORKING, PK
DOI：
10.1111/j.1582-4934.2009.00830.x
发表时间：
2009-08-01
影响因子：
5.3
作者：
Lee, Jinu;Park, Hee Suk;Lee, Suman
通讯作者：
Lee, Suman