TUBE Project: Transport-Derived Ultrafines and the Brain Effects.
TUBE Project: Transport-Derived Ultrafines and the Brain Effects.
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DOI：
10.3390/ijerph19010311
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发表时间：
2021-12-28
影响因子：
--
通讯作者：
Jalava PI
中科院分区：
文献类型：
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作者：
Martikainen MV;Aakko-Saksa P;van den Broek L;Cassee FR;Carare RO;Chew S;Dinnyes A;Giugno R;Kanninen KM;Malm T;Muala A;Nedergaard M;Oudin A;Oyola P;Pfeiffer TV;Rönkkö T;Saarikoski S;Sandström T;Schins RPF;Topinka J;Yang M;Zeng X;Westerink RHS;Jalava PI
空气污染物对呼吸系统和心血管系统的不利影响是毋庸置疑的。然而，近年来，这些器官系统以外的影响的迹象变得更加明显。与交通相关的空气污染与神经系统疾病、认知功能障碍加剧和阿尔茨海默病有关。然而，导致这些不利健康影响的确切空气污染物成分和暴露情况尚不清楚。尽管空气污染的多种成分可能发挥作用，但最近的实验研究指出超细颗粒物 (UFP) 发挥着关键作用。虽然 UFP 的重要性已得到认可，但对 UFP 的最小部分几乎一无所知，并且欧盟仅对 >23 nm 的排放进行监管。此外，排放物中半挥发性部分的作用也被忽略了。运输衍生的超细颗粒和大脑影响（TUBE）项目将增加对有害超细空气污染物以及与不良健康影响相关的半挥发性化合物的了解。通过纳入当前所有主要的燃烧和排放控制技术，TUBE 项目旨在提供有关当前交通对健康不利影响的新信息，并为决策者制定更有效的排放立法提供信息。最重要的是，TUBE 项目将包括呼吸系统以外的不良健康影响； TUBE 将评估空气污染如何影响大脑以及如何从大脑中清除空气污染颗粒。本报告的目的是描述 TUBE 项目、其背景和目标。
The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.
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DOI：
10.3390/ijerph182111568
发表时间：
2021-11-03
影响因子：
--
作者：
Calderón-Garcidueñas L;Stommel EW;Rajkumar RP;Mukherjee PS;Ayala A
通讯作者：
Ayala A
影响因子：
4.2
作者：
Hrabetov치, S;Nicholson, C
通讯作者：
Nicholson, C
影响因子：
10.4
作者：
Ajmani GS;Suh HH;Pinto JM
通讯作者：
Pinto JM
DOI：
10.3390/nano7020049
发表时间：
2017-02-22
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
--
作者：
Geiser M;Jeannet N;Fierz M;Burtscher H
通讯作者：
Burtscher H
影响因子：
15.9
作者：
Block, Michelle L.;Calderon-Garciduenas, Lilian
通讯作者：
Calderon-Garciduenas, Lilian