Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus.
Zinc-Associated Variant in SLC30A8 Gene Interacts With Gestational Weight Gain on Postpartum Glycemic Changes: A Longitudinal Study in Women With Prior Gestational Diabetes Mellitus.
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SLC30A8 基因中的锌相关变异与妊娠期体重增加对产后血糖变化的相互作用：对患有妊娠期糖尿病的女性进行的一项纵向研究。
作者：
Wang T;Liu H;Wang L;Huang T;Li W;Zheng Y;Heianza Y;Sun D;Leng J;Zhang S;Li N;Hu G;Qi L
锌转运蛋白8基因变异SLC30A8与妊娠期糖尿病（GDM）妇女产后2型糖尿病风险相关。妊娠期体重增加是产后高血糖的最大危险因素之一。在一项纵向研究中，我们评估了1071名既往患有GDM的妇女产后1-5年血糖变化中2型糖尿病相关SLC30A8 rs13266634与妊娠体重增加之间的相互作用。与妊娠26-30周相比，TT、CT和CC基因型孕妇的产后空腹血糖、口服糖耐量试验2小时血糖和血红蛋白A1c （HbA1c）水平在妊娠体重增加过多的妇女中升高，而在妊娠体重增加不足或足够的妇女中发现相反的遗传关联。在妊娠期体重增加不足、充足和过度的妇女中，每增加一个C等位基因拷贝的产后空腹血糖变化分别为- 0.18、- 0.04和0.12 mmol/L（相互作用P = 0.002）。我们还发现2小时葡萄糖和HbA1c的变化也有类似的相互作用（相互作用的P值分别为0.003和0.005）。我们的数据表明，妊娠期体重增加可能改变SLC30A8变异对长期血糖变化的影响，突出了妊娠期体重控制对预防GDM妇女产后高血糖的重要性。
Zinc transporter 8 genetic variant SLC30A8 has been associated with postpartum risk of type 2 diabetes among women with gestational diabetes mellitus (GDM). Gestational weight gain is one of the strongest risk factors for postpartum hyperglycemia. We assessed the interaction between type 2 diabetes–associated SLC30A8 rs13266634 and gestational weight gain on 1–5 years of postpartum glycemic changes in 1,071 women with prior GDM in a longitudinal study. Compared with gestation of 26–30 weeks, postpartum levels of fasting glucose, oral glucose tolerance test 2-h glucose, and hemoglobin A1c (HbA1c) increased across rs13266634 TT, CT, and CC genotypes in women with excessive gestational weight gain, whereas opposite genetic associations were found in women with inadequate or adequate gestational weight gain. Postpartum changes in fasting glucose per additional copy of the C allele were −0.18, −0.04, and 0.12 mmol/L in women with inadequate, adequate, and excessive gestational weight gain, respectively (P for interaction = 0.002). We also found similar interactions for changes in 2-h glucose and HbA1c (P for interaction = 0.003 and 0.005, respectively). Our data indicate that gestational weight gain may modify SLC30A8 variant on long-term glycemic changes, highlighting the importance of gestational weight control in the prevention of postpartum hyperglycemia in women with GDM.
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影响因子：
158.5
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5.8
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