Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults.
Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults.
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DOI：
10.4049/jimmunol.1900922
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发表时间：
2020-03-15
期刊：
影响因子：
--
通讯作者：
Kleinstein SH
中科院分区：
文献类型：
--
作者：
Avey S;Mohanty S;Chawla DG;Meng H;Bandaranayake T;Ueda I;Zapata HJ;Park K;Blevins TP;Tsang S;Belshe RB;Kaech SM;Shaw AC;Kleinstein SH
季节性流感疫苗是一种重要的公共卫生工具，但仅对一部分人有效。分子特征的鉴定为理解疫苗诱导免疫的驱动因素提供了一种机制。大多数先前报道的人流感疫苗接种的分子特征来自单一年龄组或季节，忽略了免疫衰老或疫苗组成的影响。因此，目前尚不清楚疫苗应答的免疫特征如何在多个季节随年龄变化。在这里，我们分析了连续五个疫苗接种季节的年轻人和老年人的转录景观，以确定疫苗反应的共同特征以及显著的季节差异。沿着疫苗诱导的签名在不同季节的显著变化，我们在年轻人和老年人中发现了疫苗接种后28天的共同转录签名。然而，与疫苗诱导的抗体应答相关的基因表达模式在年轻人和老年人中是不同的;例如，接种后28天杀伤细胞凝集素样受体B1（KLRB 1; CD 161）的表达增加分别对年轻人和老年人的疫苗诱导的抗体应答具有阳性和阴性预测作用。这些发现为开发更有效的流感疫苗提供了新的见解，特别是在老年人中。
The seasonal influenza vaccine is an important public health tool but is only effective in a subset of individuals. The identification of molecular signatures provides a mechanism to understand the drivers of vaccine-induced immunity. Most previously reported molecular signatures of human influenza vaccination were derived from a single age group or season, ignoring the effects of immunosenescence or vaccine composition. Thus, it remains unclear how immune signatures of vaccine response change with age across multiple seasons. Here we profile the transcriptional landscape of young and older adults over five consecutive vaccination seasons to identify shared signatures of vaccine response as well as marked seasonal differences. Along with substantial variability in vaccine-induced signatures across seasons, we uncovered a common transcriptional signature 28 days post-vaccination in both young and older adults. However, gene expression patterns associated with vaccine-induced antibody responses were distinct in young and older adults; for example, increased expression of Killer Cell Lectin Like Receptor B1 (KLRB1; CD161) 28 days post-vaccination positively and negatively predicted vaccine-induced antibody responses in young and older adults, respectively. These findings contribute new insights for developing more effective influenza vaccines, particularly in older adults.
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人白细胞介素17产生的细胞起源于CD161+ CD4+ T细胞前体。
影响因子：
15.3
作者：
Cosmi, Lorenzo;De Palma, Raffaele;Santarlasci, Veronica;Maggi, Laura;Capone, Manuela;Frosali, Francesca;Rodolico, Gabriella;Querci, Valentina;Abbate, Gianfranco;Angeli, Roberta;Berrino, Liberato;Fambrini, Massimiliano;Caproni, Marzia;Tonelli, Francesco;Lazzeri, Elena;Parronchi, Paola;Liotta, Francesco;Maggi, Enrico;Romagnani, Sergio;Annunziato, Francesco
通讯作者：
Annunziato, Francesco
影响因子：
4.4
作者：
Aldemir, H;Prod'homme, V;Braud, VM
通讯作者：
Braud, VM
影响因子：
6.7
作者：
Khaperskyy DA;Schmaling S;Larkins-Ford J;McCormick C;Gaglia MM
通讯作者：
Gaglia MM
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.7
作者：
Beran, Jiri;Wertzova, Veronika;Devaster, Jeanne-Marie
通讯作者：
Devaster, Jeanne-Marie