Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation.
Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation.
复制标题
因COVID-19住院的成人中的严重谷氨酸缺乏、氧化应激和氧化损伤：GlyNAC（甘氨酸和N-乙酰半胱氨酸）补充的意义。
DOI：
10.3390/antiox11010050
复制
发表时间：
2021-12-27
期刊：
影响因子：
--
通讯作者：
Sekhar RV
中科院分区：
文献类型：
--
作者：
Kumar P;Osahon O;Vides DB;Hanania N;Minard CG;Sekhar RV
人类正在与一种名为 COVID-19 的呼吸道大流行性肺炎作斗争，该肺炎已导致数百万人住院和死亡。 COVID-19 的病情恶化一波又一波地发生，持续挑战着全球医疗保健系统。因此，迫切需要了解 COVID-19 导致健康恶化的所有机制，以促进制定保护策略。氧化应激 (OxS) 是由过量的活性氧 (ROS) 引起的有害状况，通常可被抗氧化剂（其中最丰富的谷胱甘肽 (GSH)）中和。由于抗氧化防御受损，GSH 缺乏会导致 OxS 扩增。由于对 COVID-19 感染中的 GSH 或 OxS 知之甚少，我们测量了 60 名因 COVID-19 住院的成年患者的 GSH、TBARS（OxS 标记物）和 F2-异前列烷（氧化损伤标记物）浓度。与未感染的对照组相比，所有年龄段的 COVID-19 患者均存在严重的 GSH 缺乏、OxS 增加和氧化损伤升高，且随着年龄的增长而恶化。这些缺陷也存在于较年轻的年龄组中，而这些缺陷通常不会发生。由于临床试验已证明补充 GlyNAC（甘氨酸和 N-乙酰半胱氨酸的组合）可以快速改善 GSH 缺乏、OxS 和氧化损伤，因此补充 GlyNAC 对于对抗 COVID-19 感染患者的这些缺陷具有重要意义，值得紧急研究。
Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves that continually challenge healthcare systems globally. Therefore, there is an urgent need to understand all mechanisms by which COVID-19 results in health deterioration to facilitate the development of protective strategies. Oxidative stress (OxS) is a harmful condition caused by excess reactive-oxygen species (ROS) and is normally neutralized by antioxidants among which Glutathione (GSH) is the most abundant. GSH deficiency results in amplified OxS due to compromised antioxidant defenses. Because little is known about GSH or OxS in COVID-19 infection, we measured GSH, TBARS (a marker of OxS) and F2-isoprostane (marker of oxidant damage) concentrations in 60 adult patients hospitalized with COVID-19. Compared to uninfected controls, COVID-19 patients of all age groups had severe GSH deficiency, increased OxS and elevated oxidant damage which worsened with advancing age. These defects were also present in younger age groups, where they do not normally occur. Because GlyNAC (combination of glycine and N-acetylcysteine) supplementation has been shown in clinical trials to rapidly improve GSH deficiency, OxS and oxidant damage, GlyNAC supplementation has implications for combating these defects in COVID-19 infected patients and warrants urgent investigation.
登录
查看更多内容
影响因子：
3.9
作者：
Moreno Fernández-Ayala DJ;Navas P;López-Lluch G
通讯作者：
López-Lluch G
影响因子：
5.8
作者：
Assimakopoulos, Stelios F.;Aretha, Diamanto;Marangos, Markos
通讯作者：
Marangos, Markos
影响因子：
4.7
作者：
Kumar P;Liu C;Suliburk JW;Minard CG;Muthupillai R;Chacko S;Hsu JW;Jahoor F;Sekhar RV
通讯作者：
Sekhar RV
影响因子：
11.4
作者：
Chen, Yan-Mei;Zheng, Yuanting;Zhang, Yong-Zhen
通讯作者：
Zhang, Yong-Zhen
我的衰老和炎症：老年人严重Covid-19的危险因素。
影响因子：
7.3
作者：
Pietrobon AJ;Teixeira FME;Sato MN
通讯作者：
Sato MN