Base excision repair: a critical player in many games.
Base excision repair: a critical player in many games.
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DOI：
10.1016/j.dnarep.2014.03.030
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发表时间：
2014-07
期刊：
影响因子：
3.8
通讯作者：
Wallace, Susan S.
中科院分区：
文献类型：
--
作者：
Wallace, Susan S.
关键词：
这个观点回顾了基地切除修复的许多方面，从10,000英尺的Vantage位置，并提供了一个人的看法，该领域的领导。酶的功能被认为是下的X-射线衍射和单分子研究的透镜。在染色质和端粒的碱基切除修复，表达调控和翻译后修饰的作用也讨论了酶的活性，细胞定位和相互作用的合作伙伴的背景下。还讨论了碱基切除修复在主动去甲基化和靶向氧化的转录激活中发挥的专门作用，以及碱基切除修复在体细胞超突变和类转换重组的免疫过程中的作用及其可能参与逆转录病毒感染。最后，氧化损伤及其修复的复杂性和它与神经退行性疾病的联系，以及碱基切除修复作为肿瘤抑制因子的作用，在损伤，修复和衰老的背景下进行检查。通过概述许多与碱基切除修复相关的尚未解开的谜团，希望这种观点将激发人们对该领域的进一步兴趣。
This perspective reviews the many dimensions of base excision repair from a 10,000 foot vantage point and provides one person’s view on where the field is headed. Enzyme function is considered under the lens of X-ray diffraction and single molecule studies. Base excision repair in chromatin and telomeres, regulation of expression and the role of posttranslational modifications are also discussed in the context of enzyme activities, cellular localization and interacting partners. The specialized roles that base excision repair play in transcriptional activation by active demethylation and targeted oxidation as well as how base excision repair functions in the immune processes of somatic hypermutation and class switch recombination and its possible involvement in retroviral infection are also discussed. Finally the complexities of oxidative damage and its repair and its link to neurodegenerative disorders, as well as the role of base excision repair as a tumor suppressor are examined in the context of damage, repair and aging. By outlining the many base excision repair-related mysteries that have yet to be unraveled, hopefully this perspective will stimulate further interest in the field.
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人胃癌相关的DNA聚合酶β变异D160N是一种诱导细胞转化的突变器。
影响因子：
3.8
作者：
Donigan, Katherine A.;Hile, Suzanne E.;Eckert, Kristin A.;Sweasy, Joann B.
通讯作者：
Sweasy, Joann B.
影响因子：
16.8
作者：
通讯作者：
--
DOI：
10.1126/science.1170633
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
de Lange T
通讯作者：
de Lange T
影响因子：
64.5
作者：
Alt FW;Zhang Y;Meng FL;Guo C;Schwer B
通讯作者：
Schwer B
影响因子：
5.6
作者：
Berquist, Brian R.;McNeill, Daniel R.;Wilson, David M., III
通讯作者：
Wilson, David M., III