Detection and Modulation of Olfactory Sensing Receptors in Carnivorous Rainbow Trout (Oncorhynchus mykiss) Fed from First Feeding with Plant-Based Diet.
Detection and Modulation of Olfactory Sensing Receptors in Carnivorous Rainbow Trout (Oncorhynchus mykiss) Fed from First Feeding with Plant-Based Diet.
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DOI：
10.3390/ijms23042123
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发表时间：
2022-02-14
影响因子：
5.6
通讯作者：
Roy J
中科院分区：
文献类型：
--
作者：
Heraud C;Hirschinger T;Baranek E;Larroquet L;Surget A;Sandres F;Lanuque A;Terrier F;Roy J
嗅觉是由不同的嗅觉感受器家族介导的，传递着重要的饮食信息，对生长和生存至关重要。本研究的目的是阐明感官嗅觉通路在食肉性虹鳟鱼(RT，Oncorhynchus mykis)从首次摄食到8月龄的摄食行为调节中所起的作用。与商业日粮相比，完全以植物为基础的日粮RT在早期阶段就表现出与饲料摄入量相关的显著变化的生长性能。对RT基因组数据库的详尽研究发现，3个犁鼻1型受体(ORA)、10个犁鼻2型受体(OLFC)和14个主要嗅觉受体(MOR)基因在感觉器官中高表达，表明它们具有潜在的功能。摄食后的基因表达表明部分OLFC(Olfcg6)和MOR(mor103，-107，-112，-113，-133)受体家族基因在RT中对嗅觉感知具有重要作用。Ora1a基因表明，以商业类饲料喂养的鱼参与了嗅觉感知，而ora5b、mor118、mor124和olfch1基因则表明，以植物性饲料喂养的鱼参与了嗅觉感知。结果表明，植物性饮食对嗅觉通路的调节以及与嗅觉驱动行为相关的脑区单胺能神经传递的影响。这些结果表明，在RT中，摄食行为是通过嗅觉检测和嗅觉驱动的行为通路来调节的。
Sense of smell is mediated by diverse families of olfactory sensing receptors, conveying important dietary information, fundamental for growth and survival. The aim of this study was to elucidate the role of the sensory olfactory pathways in the regulation of feeding behavior of carnivorous rainbow trout (RT, Oncorhynchus mykiss), from first feeding until 8 months. Compared to a commercial diet, RT fed with a total plant-based diet showed drastically altered growth performance associated with feed intake from an early stage. Exhaustive examination of an RT genome database identified three vomeronasal type 1 receptor-like (ORA), 10 vomeronasal type 2 receptor-like (OLFC) and 14 main olfactory receptor (MOR) genes, all highly expressed in sensory organs, indicating their potential functionality. Gene expression after feeding demonstrated the importance in olfactory sensing perception of some OLFC (olfcg6) and MOR (mor103, -107, -112, -113, -133) receptor family genes in RT. The gene ora1a showed evidence of involvement in olfactory sensing perception for fish fed with a commercial-like diet, while ora5b, mor118, mor124 and olfch1 showed evidence of involvement in fish fed with a plant-based diet. Results indicated an impact of a plant-based diet on the regulation of olfactory sensing pathways as well as influence on monoaminergic neurotransmission in brain areas related to olfactory-driven behaviors. The overall findings suggest that feeding behavior is mediated through olfactory sensing detection and olfactory-driven behavior pathways in RT.
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影响因子：
2.9
作者：
Rink, E;Wullimann, MF
通讯作者：
Wullimann, MF
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DOI：
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发表时间：
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