Maternal inflammation and its ramifications on fetal neurodevelopment.
Maternal inflammation and its ramifications on fetal neurodevelopment.
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DOI：
10.1016/j.it.2022.01.007
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发表时间：
2022-03
影响因子：
16.8
通讯作者：
Huh, Jun R.
中科院分区：
文献类型：
--
作者：
Kwon, Ho-Keun;Choi, Gloria B.;Huh, Jun R.
妊娠期暴露于由感染或其他炎性损伤引起的高度炎症与儿童神经发育和精神疾病的发病有关。啮齿动物模型为这种母体免疫激活（MIA）如何破坏大脑发育提供了独特的见解。在这里，我们讨论了涉及的关键免疫因素，强调在确定MIA的分子和细胞途径的最新进展，并审查母体免疫系统如何影响胎儿发育。我们还研究了微生物组在塑造母体免疫功能和自闭症样表型发展中的作用。全面了解MIA中肠道细菌-免疫-神经相互作用对于制定高危孕妇的诊断和治疗措施以及确定治疗炎症诱导的神经发育障碍的靶点至关重要。
Exposure to heightened inflammation in pregnancy caused by infections or other inflammatory insults has been associated with the onset of neurodevelopmental and psychiatric disorders in children. Rodent models have provided unique insights into how this maternal immune activation (MIA) disrupts brain development. Here, we discuss the key immune factors involved, highlight recent advances in determining the molecular and cellular pathways of MIA, and review how the maternal immune system affects fetal development. We also examine the roles of microbiomes in shaping maternal immune function and the development of autism-like phenotypes. A comprehensive understanding of the gut bacteria-immune-neuro interaction in MIA is essential for developing diagnostic and therapeutic measures for high-risk pregnant women and identifying targets for treating inflammation-induced neurodevelopmental disorders.
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