Drug discovery in psychiatric illness: mining for gold.
Drug discovery in psychiatric illness: mining for gold.
复制标题
精神疾病的药物发现：金矿开采。
DOI：
10.1093/schbul/sbn194
复制
发表时间：
2009
影响因子：
6.6
通讯作者：
Kafkafi,Neri
中科院分区：
文献类型：
--
作者：
Elmer,GregI;Kafkafi,Neri
The discovery of truly efficacious treatments that lead to full recovery is a daunting task in psychiatric illness. A systems-based orientation toin vivopharmacology has been suggested as a way to transform psychiatric drug discovery and development. A critical catalyst in the success of recent systems biology efforts has been the incorporation of data mining strategies. Our approach to the drug discovery problem has been to utilize the whole animal to provide a systems response that is subsequently mined for predictive attributes with known psychopharmacological value. Ourin vivodata mining approach, termed Pattern Array, establishes a framework for screening novel chemical entities based upon a response that represents the net pharmacological effect on the system of interest, namely the central nervous system (CNS). Large scale screening of small molecules by non-conventional approaches such as this at a systems level may improve the identification of novel chemical entities with psychiatric utility. This type of approach will compliment the more labor-intensive models based upon construct validity. It will take the collective effort of many disciplines and numerous strategies in close association with clinical colleagues to address quality of life issues and breakthrough treatment barriers in psychiatric illness.
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