Malignancy risk in patients with giant cell arteritis: a population-based cohort study.
Malignancy risk in patients with giant cell arteritis: a population-based cohort study.
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DOI：
10.1002/acr.20062
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发表时间：
2010-02
影响因子：
4.7
通讯作者：
Warrington, Kenneth J.
中科院分区：
文献类型：
--
作者：
Kermani, Tanaz A.;Schaefer, Valentin S.;Crowson, Cynthia S.;Hunder, Gene G.;Gabriel, Sherine E.;Ytterberg, Steven R.;Matteson, Eric L.;Warrington, Kenneth J.
确定巨细胞动脉炎（GCA）患者人群队列与年龄和性别匹配的参考受试者相比的癌症发病率。利用罗切斯特流行病学项目（REP）的资源，确定了1950年1月1日至2004年12月31日期间诊断的所有GCA事件病例。对于每例GCA患者，选择2例性别、年龄和病史长度相似的无GCA的受试者。病理组织学诊断为恶性肿瘤。随访患者直至死亡、末次联系或2006年12月31日。我们的研究包括204例GCA患者和407例非GCA受试者。GCA队列有163名（79%）女性和41名（21%）男性，平均年龄76.0岁（± 8.2岁），中位随访时间7.7年。非GCA队列包括325例（80%）女性和82例（20%）男性，平均年龄75.6岁（± 8.4岁），中位随访时间8.1年。随访期间，46例GCA患者和76例非GCA受试者发生癌症（HR：1.26; 95% CI：0.87，1.83）。吸烟的调整并没有改变结果。GCA患者1年、10年和20年任何恶性肿瘤的累积发生率分别为5.9%、33.6%和50.0%，非GCA患者分别为2.6%、27.0%和47.0%。两组之间的血液学或实体恶性肿瘤无差异。结肠癌在GCA组中更常见（p=0.07）。两个队列中癌症后的死亡率相似（HR：0.80; 95% CI：0.52，1.24）。GCA患者在诊断后患第一种癌症的风险不会增加。
To determine the incidence of cancer in a population-based cohort of patients with giant cell arteritis (GCA) compared to age- and gender-matched referent subjects. Using the resources of the Rochester Epidemiology Project (REP), all incident cases of GCA diagnosed between January 1, 1950 and December 31, 2004 were identified. For each GCA patient, 2 subjects without GCA of the same sex, similar age and length of medical history were selected. Diagnosis of malignancy was made by histopathology. Patients were followed until death, last contact, or December 31, 2006. Our study included 204 GCA patients and 407 non-GCA subjects. The GCA cohort had 163 (79%) women and 41 (21%) men, mean age 76.0 years (± 8.2 years), median follow-up 7.7 years. The non-GCA cohort consisted of 325 (80%) women and 82 (20%) men, mean age 75.6 years (± 8.4 years), median follow-up 8.1 years. During follow-up, 46 GCA patients and 76 non-GCA subjects developed cancer (HR: 1.26; 95% CI: 0.87, 1.83). Adjustment for smoking did not alter the results. The 1, 10 and 20 year cumulative incidences of any malignancy were 5.9%, 33.6% and 50.0% among GCA patients and 2.6%, 27.0% and 47.0% among non-GCA patients. There were no differences in hematologic or solid malignancies between both groups. Colon cancer appeared more commonly in the GCA group (p=0.07). Mortality following cancer was similar in both cohorts (HR: 0.80; 95% CI: 0.52, 1.24). GCA patients are not at increased risk of first cancer after diagnosis.
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影响因子：
8.6
作者：
Elbaz, A;Peterson, BJ;Rocca, WA
通讯作者：
Rocca, WA
影响因子：
3.4
作者：
Espinosa, G;Font, J;Ingelmo, M
通讯作者：
Ingelmo, M
影响因子：
5.1
作者：
Weyand, Cornelia M.;Goronzy, Jorg J.
通讯作者：
Goronzy, Jorg J.
影响因子：
2.3
作者：
Kremers, HM;Crowson, CS;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
120.7
作者：
Erlinger, TP;Platz, EA;Helzlsouer, KJ
通讯作者：
Helzlsouer, KJ