Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.
Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.
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DOI：
10.1038/srep09083
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发表时间：
2015-03-13
影响因子：
4.6
通讯作者：
Taniguchi M
中科院分区：
文献类型：
--
作者：
Hata R;Izukuri K;Kato Y;Sasaki S;Mukaida N;Maehata Y;Miyamoto C;Akasaka T;Yang X;Nagashima Y;Takeda K;Kiyono T;Taniguchi M
癌症进展涉及癌变、肿瘤大小增加和转移。在这里，我们研究了过度表达CXC趋化因子配体14（CXCL 14）对这些过程中使用CXCL 14/BRAK（CXCL 14）转基因（Tg）小鼠。AOM/DSS诱导的大肠癌发生率在这些小鼠中显著低于同基因野生型C57 BL/6（Wt）小鼠。当将肿瘤细胞注射到这些小鼠中时，Tg小鼠中发展的肿瘤的大小和动物肺中转移性结节的数量总是显著低于Wt小鼠。在注射肿瘤细胞之前和之后向小鼠注射抗脱唾液酸基-GM 1抗体减弱了CXCL 14对肿瘤生长和转移的抑制作用，表明NK细胞活性在CXCL 14介导的肿瘤生长和转移抑制过程中起重要作用。当CXCL 14在B16黑色素瘤细胞中表达时，NK细胞对转移的重要性也得到支持。此外，对于Tg小鼠，肿瘤细胞注射后的存活率显著增加。由于这些Tg小鼠没有表现出明显的异常，我们建议CXCL 14是一个有前途的肿瘤抑制/预防的分子靶点。
Cancer progression involves carcinogenesis, an increase in tumour size, and metastasis. Here, we investigated the effect of overexpressed CXC chemokine ligand 14 (CXCL14) on these processes by using CXCL14/BRAK (CXCL14) transgenic (Tg) mice. The rate of AOM/DSS-induced colorectal carcinogenesis in these mice was significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice. When tumour cells were injected into these mice, the size of the tumours that developed and the number of metastatic nodules in the lungs of the animals were always significantly lower in the Tg mice than in the Wt ones. Injection of anti-asialo-GM1 antibodies to the mice before and after injection of tumour cells attenuated the suppressing effects of CXCL14 on the tumor growth and metastasis, suggesting that NK cell activity played an important role during CXCL14-mediated suppression of tumour growth and metastasis. The importance of NK cells on the metastasis was also supported when CXCL14 was expressed in B16 melanoma cells. Further, the survival rates after tumour cell injection were significantly increased for the Tg mice. As these Tg mice showed no obvious abnormality, we propose that CXCL14 to be a promising molecular target for cancer suppression/prevention.
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托瑞米芬或他莫昔芬治疗绝经前雌激素和孕激素受体阳性乳腺癌患者的生存结果和副作用的比较：一项回顾性队列研究
影响因子：
3.8
作者：
Gu R;Jia W;Zeng Y;Rao N;Hu Y;Li S;Wu J;Jin L;Chen L;Long M;Chen K;Chen L;Xiao Q;Wu M;Song E;Su F
通讯作者：
Su F
影响因子：
4.7
作者：
Hirsch, Daniela;Barker, Nick;Gaiser, Timo
通讯作者：
Gaiser, Timo
影响因子：
--
作者：
Izukuri, Kazuhito;Ito, Shin;Hata, Ryu-Ichiro
通讯作者：
Hata, Ryu-Ichiro
影响因子：
4.4
作者：
Chen, Limo;Guo, Linjie;Han, Shuhua
通讯作者：
Han, Shuhua
DOI：
10.1006/bbrc.1999.0257
发表时间：
1999-02-24
影响因子：
3.1
作者：
Hromas, R;Broxmeyer, HE;Hou, YH
通讯作者：
Hou, YH