The potential to predict the course of childhood asthma.
The potential to predict the course of childhood asthma.
复制标题
DOI：
10.1586/17476348.2014.879826
复制
发表时间：
2014-04
影响因子：
3.9
通讯作者：
Sears MR
中科院分区：
文献类型：
--
作者：
Belsky DW;Sears MR
许多儿童在学龄前或幼儿期都有喘息的经历。随着孩子的成长，很大一部分症状会消失，但其他人则会有持续性和麻烦的哮喘，这可能是终身的。预测幼儿病程的工具是家庭和临床医生的首要任务。这篇综述总结了几项纵向的基于人群的出生队列研究的证据，这些研究已经确定了儿童哮喘持续和缓解的危险因素。这些因素包括临床特征、环境和其他暴露、家族因素、过敏性炎症的生物标志物、肺功能和气道反应性的测量以及遗传变异。这篇综述还介绍了多基因风险和遗传风险评分的概念，并描述了最近的一项研究结果，该研究表明，使用遗传信息预测儿童哮喘的病程是有希望的。最后，我们讨论的影响和未来的方向。
Many children experience pre-school or early childhood wheezing. In a significant proportion symptoms disappear as the child grows, but others have persistent and troublesome asthma which can be life-long. Tools to predict course of disease in young children are a priority for families and clinicians. This review summarizes evidence from several longitudinal population-based birth-cohort studies that have identified risk factors for persistence and remission of childhood asthma. These factors include clinical characteristics, environmental and other exposures, familial factors, biomarkers of allergic inflammation, measurements of lung function and airway responsiveness, and genetic variants. This review also introduces the concept of polygenic risk and genetic risk scores, and describes results from a recent study that suggests promise for the use of genetic information in predicting the course of childhood asthma. We conclude with a discussion of implications and future directions.
登录
查看更多内容
影响因子：
168.9
作者：
Ferreira, Manuel A. R.;Matheson, Melanie C.;Duffy, David L.;Marks, Guy B.;Hui, Jennie;Le Souef, Peter;Danoy, Patrick;Baltic, Svetlana;Nyholt, Dale R.;Jenkins, Mark;Hayden, Catherine;Willemsen, Gonneke;Ang, Wei;Kuokkanen, Mikko;Beilby, John;Cheah, Faang;de Geus, Eco J. C.;Ramasamy, Adaikalavan;Vedantam, Sailaja;Salomaa, Veikko;Madden, Pamela A.;Heath, Andrew C.;Hopper, John L.;Visscher, Peter M.;Musk, Bill;Leeder, Stephen R.;Jarvelin, Marjo-Riitta;Pennell, Craig;Boomsma, Dorret I.;Hirschhorn, Joel N.;Walters, Haydn;Martin, Nicholas G.;James, Alan;Jones, Graham;Abramson, Michael J.;Robertson, Colin F.;Dharmage, Shyamali C.;Brown, Matthew A.;Montgomery, Grant W.;Thompson, Philip J.
通讯作者：
Thompson, Philip J.
影响因子：
158.5
作者：
Bouzigon, Emmanuelle;Corda, Eve;Demenais, Florence
通讯作者：
Demenais, Florence
影响因子：
3.5
作者：
Evans, David M.;Visscher, Peter M.;Wray, Naomi R.
通讯作者：
Wray, Naomi R.
影响因子：
--
作者：
JENKINS, MA;HOPPER, JL;GILES, GG
通讯作者：
GILES, GG
影响因子：
76.2
作者：
Belsky, Daniel W.;Sears, Malcolm R.;Caspi, Avshalom
通讯作者：
Caspi, Avshalom