Biomarker-based HIV incidence in a community sample of men who have sex with men in Paris, France.
Biomarker-based HIV incidence in a community sample of men who have sex with men in Paris, France.
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DOI：
10.1371/journal.pone.0039872
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Semaille C
中科院分区：
文献类型：
--
作者：
Le Vu S;Velter A;Meyer L;Peytavin G;Guinard J;Pillonel J;Barin F;Semaille C
法国基于人口的艾滋病毒发病率估计显示，男男性行为者是受影响最严重的人群，每年占新感染人数的近一半。我们试图估计艾滋病毒的发病率之间的性活跃的男男性接触者在巴黎同性恋社区的社交场所。2009年，在酒吧、桑拿浴室和密室等商业场所进行了一项横断面调查。我们收集了一份行为问卷和血液样本。对样本进行HIV感染检测，阳性样本然后通过近期HIV-1感染酶免疫测定法（EIA-RI）检测近期感染。我们评估了感染者中抗逆转录病毒治疗的存在，以在确定近期感染的算法中排除接受过治疗的患者。计算基于生物标志物的横断面发生率估计值。我们招募了886名MSM参与者，其中157人（18%）检测出HIV阳性。在知道自己被感染的阳性个体中，75%的EIA-RI阳性结果是由于ART。在157例HIV阳性标本中，15例被认为是最近感染的。总体HIV发病率估计为3.8%人年（py）[95%CI：1.5-6.2]。尽管差异不显著，但在前一年HIV检测阴性的男性中，发病率估计为3.5% py [0.1-6.1]，在调查前一年以上进行最后一次HIV检测或从未检测的男性中，发病率估计为4.8% py [0.1-10.6]。35岁以下男性的发病率估计为4.1% py [0-8.3]，老年男性为2.5% py [0-5.4]。这是第一个以社区为基础的调查，估计艾滋病毒在法国男男性行为者的发病率。它包括抗逆转录病毒疗法检测，并揭示了性活跃的个人中艾滋病毒传播的高水平，尽管艾滋病毒检测的吸收率很高。这些数据要求针对从事高风险行为的男男性行为者制定有效的预防方案。
Population-based estimates of HIV incidence in France have revealed that men who have sex with men (MSM) are the most affected population and contribute to nearly half of new infections each year. We sought to estimate HIV incidence among sexually active MSM in Paris gay community social venues. A cross-sectional survey was conducted in 2009 in a sample of commercial venues such as bars, saunas and backrooms. We collected a behavioural questionnaire and blood sample. Specimens were tested for HIV infection and positive specimens then tested for recent infection by the enzyme immunoassay for recent HIV-1 infection (EIA-RI). We assessed the presence of antiretroviral therapy among infected individuals to rule out treated patients in the algorithm that determined recent infection. Biomarker-based cross-sectional incidence estimates were calculated. We enrolled 886 MSM participants among which 157 (18%) tested HIV positive. In positive individuals who knew they were infected, 75% of EIA-RI positive results were due to ART. Of 157 HIV positive specimens, 15 were deemed to be recently infected. The overall HIV incidence was estimated at 3.8% person-years(py) [95%CI: 1.5–6.2]. Although differences were not significant, incidence was estimated to be 3.5% py [0.1–6.1] in men having had a negative HIV test in previous year and 4.8% py [0.1–10.6] in men having had their last HIV test more than one year before the survey, or never tested. Incidence was estimated at 4.1% py [0–8.3] in men under 35 years and 2.5% py [0–5.4] in older men. This is the first community-based survey to estimate HIV incidence among MSM in France. It includes ART detection and reveals a high level of HIV transmission in sexually active individuals, despite a high uptake of HIV testing. These data call for effective prevention programs targeting MSM engaged in high-risk behaviours.
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作者：
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DOI：
10.1097/qai.0b013e318058a01e
发表时间：
2007-06-01
影响因子：
3.6
作者：
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通讯作者：
Hart, Graham J.