New genes as drivers of phenotypic evolution.

New genes as drivers of phenotypic evolution.
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DOI:
10.1038/nrg3521
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发表时间:
2013-09
期刊:
Nature reviews. Genetics
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其他
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在进化过程中,基因组获得新的遗传元素作为功能和表型多样性的来源,包括在最近进化中产生的新基因。在过去的几年中,在理解新基因的进化和表型效应方面取得了实质性进展。特别是,一种新出现的观点是,尽管新基因只存在于一小部分物种的基因组中,但它们可以在包括发育、繁殖、大脑功能和行为在内的基本生物过程中迅速进化出不可或缺的角色。新基因如何发挥这些作用的分子基础已经开始被描述出来。这些最近的发现以精确的分辨率为我们对生物多样性的广泛理解提供了新的见解。
During the course of evolution, genomes acquire novel genetic elements as sources of functional and phenotypic diversity, including new genes that originated in recent evolution. In the past few years, substantial progress has been made in understanding the evolution and phenotypic effects of new genes. In particular, an emerging picture is that new genes, despite being present in the genomes of only a subset of species, can rapidly evolve indispensable roles in fundamental biological processes, including development, reproduction, brain function and behaviour. The molecular underpinnings of how new genes can develop these roles are starting to be characterized. These recent discoveries yield fresh insights into our broad understanding of biological diversity at refined resolution.
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