Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.
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DOI：
10.1016/j.ccr.2011.12.004
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发表时间：
2012-01-17
期刊：
影响因子：
50.3
通讯作者：
Wang TC
中科院分区：
文献类型：
--
作者：
Quante M;Bhagat G;Abrams JA;Marache F;Good P;Lee MD;Lee Y;Friedman R;Asfaha S;Dubeykovskaya Z;Mahmood U;Figueiredo JL;Kitajewski J;Shawber C;Lightdale CJ;Rustgi AK;Wang TC
食管腺癌（EAC）起源于巴雷特食管（BE），与反流性食管炎相关的膀胱样柱状化生。在BE的转基因小鼠模型中，食管中白细胞介素-1 β的过度表达与人类病理学相似，伴有食管炎、Barrett样化生和EAC的演变。组织学和基因特征与人BE非常相似，TFF 2、Bmp 4、Cdx 2、Notch 1和IL-6上调。胆汁酸和/或亚硝胺可加速BE和EAC的发展，而IL-6缺乏则可抑制BE和EAC的发展。BE中存在的Lgr 5+贲门干细胞能够谱系追踪早期BE病变。我们的数据表明，BE和EAC来自胃祖细胞，这是由于肿瘤促进性IL-1β-IL-6信号级联和Dll 1依赖性Notch信号。
Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression of interleukin-1β phenocopies human pathology with evolution of esophagitis, Barrett’s-like metaplasia and EAC. Histopathology and gene signatures resembled closely human BE, with upregulation of TFF2, Bmp4, Cdx2, Notch1 and IL-6. The development of BE and EAC was accelerated by exposure to bile acids and/or nitrosamines, and inhibited by IL-6 deficiency. Lgr5+ gastric cardia stem cells present in BE were able to lineage trace the early BE lesion. Our data suggest that BE and EAC arise from gastric progenitors due to a tumor-promoting IL-1β-IL-6 signaling cascade and Dll1-dependent Notch signaling.
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DOI：
10.1016/s1091-255x(98)80021-8
发表时间：
1998-05-01
期刊：
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
影响因子：
--
作者：
Fein, M;Peters, J H;DeMeester, T R
通讯作者：
DeMeester, T R
影响因子：
82.9
作者：
Fox, JG;Beck, P;Nagler-Anderson, C
通讯作者：
Nagler-Anderson, C
影响因子：
9.8
作者：
Gough, MD;Ackroyd, R;Bird, NC
通讯作者：
Bird, NC
影响因子：
50.3
作者：
Bollrath, Julia;Phesse, Toby J.;Greten, Florian R.
通讯作者：
Greten, Florian R.
影响因子：
64.5
作者：
Benedito, Rui;Roca, Cristina;Adams, Ralf H.
通讯作者：
Adams, Ralf H.