Spatially constrained incoherent motion method improves diffusion-weighted MRI signal decay analysis in the liver and spleen.
Spatially constrained incoherent motion method improves diffusion-weighted MRI signal decay analysis in the liver and spleen.
复制标题
空间约束不相干运动方法改善了肝脏和脾脏中的扩散加权 MRI 信号衰减分析。
DOI：
10.1118/1.4915495
复制
发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Freiman,Moti
中科院分区：
文献类型：
--
作者：
Taimouri,Vahid;Afacan,Onur;Perez-Rossello,JeannetteM;Callahan,MichaelJ;Mulkern,RobertV;Warfield,SimonK;Freiman,Moti
目的通过与独立体素体素内非相干运动(IVIM)模型的比较，评价空间约束非相干运动(SCIM)方法在提高肝脏和脾弥散加权MRI快、慢扩散参数估计精度和稳健性方面的作用。方法收集29例受试者(5例正常人和24例回肠克罗恩病患者)的扩散加权MRI(DW-MRI)数据。我们通过比较SCIM模型和独立体素IVIM模型得到的估计的方差，评估了参数估计对不同的b值组合(即4b值和7b值)的稳健性。我们还通过比较SCIM参数估计和IVIM参数估计的变异系数(CV)来评估参数估计精度的提高。结果对于不同的B值组合，SCIM方法比IVIM方法更稳健(肝和脾的变异系数高达70%)。此外，SCIM法参数估计的CV值明显低于IVIM法的重复采集和信号平均估计，尤其是肝和脾的快扩散参数(CVIVIM=46.61±11.22，CVSCIM=16.85±2.160，p<；0.001)和脾(CVIVIM=95.15±19.82，CVSCIM=52.55±1.91，p<；0.001)。
PurposeTo evaluate the effect of the spatially constrained incoherent motion (SCIM) method on improving the precision and robustness of fast and slow diffusion parameter estimates from diffusion‐weighted MRI in liver and spleen in comparison to the independent voxel‐wise intravoxel incoherent motion (IVIM) model.MethodsWe collected diffusion‐weighted MRI (DW‐MRI) data of 29 subjects (5 healthy subjects and 24 patients with Crohn's disease in the ileum). We evaluated parameters estimates’ robustness against different combinations ofb‐values (i.e., 4b‐values and 7b‐values) by comparing the variance of the estimates obtained with the SCIM and the independent voxel‐wise IVIM model. We also evaluated the improvement in the precision of parameter estimates by comparing the coefficient of variation (CV) of the SCIM parameter estimates to that of the IVIM.ResultsThe SCIM method was more robust compared to IVIM (up to 70% in liver and spleen) for different combinations ofb‐values. Also, the CV values of the parameter estimations using the SCIM method were significantly lower compared to repeated acquisition and signal averaging estimated using IVIM, especially for the fast diffusion parameter in liver (CVIV IM= 46.61 ± 11.22, CVSCIM= 16.85 ± 2.160,p< 0.001) and spleen (CVIV IM= 95.15 ± 19.82, CVSCIM= 52.55 ± 1.91,p< 0.001).ConclusionsThe SCIM method characterizes fast and slow diffusion more precisely compared to the independent voxel‐wise IVIM model fitting in the liver and spleen.
影响因子：
5.5
作者：
Qayyum, Aliya
通讯作者：
Qayyum, Aliya
影响因子：
29.4
作者：
Lewis JD
通讯作者：
Lewis JD
影响因子：
5.9
作者：
Andreou, A.;Koh, D. M.;Orton, M. R.
通讯作者：
Orton, M. R.