Typologies of illicit drug use in mid-adulthood: a quasi-longitudinal latent class analysis in a community-based sample of twins.
Typologies of illicit drug use in mid-adulthood: a quasi-longitudinal latent class analysis in a community-based sample of twins.
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DOI：
10.1111/add.15225
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Slutske WS
中科院分区：
文献类型：
--
作者：
Dash GF;Martin NG;Agrawal A;Lynskey MT;Slutske WS
To identify drug use typologies based on substances used and persistence of use over two time points, use a genetically-informed design to explore twin concordance of and genetic influence on the use typologies, and compare patterns of declined/discontinued (“desistant”) and persistent drug use on drug use correlates. Latent class analysis was applied to data from a cross-sectional self-report survey on current and past drug use. Use characteristics, use disorder, and psychiatric problems were compared across classes. Computer-assisted telephone interview in respondents’ homes. A total of 3,785 individual twins and siblings (1,365 men, 2,420 women; Mage=32) from the Australian Twin Registry Cohort III. A comprehensive interview assessed prior to past year and past year use of cannabis, stimulants, cocaine/crack, hallucinogens, opioids, sedatives, inhalants, dissociatives, and solvents; age of first use; opportunity to use; peer drug use; attention deficit/hyperactivity, conduct, antisocial personality, depressive, and substance use disorders; and suicidality. A five-class solution emerged: no/low use (50%), desistant cannabis use (23%), desistant party drug use (18%), persistent prescription drug misuse (4%), and persistent polydrug use (5%). Twin concordances were higher among monozygotic (ⱪ=.30–.35) than dizygotic pairs (same-sex ⱪ=.19–.20; opposite sex ⱪ=.07), and biometric modeling suggested that the persistent polydrug use class, in particular, was highly heritable (a2=.94). Conduct disorder (OR=2.40), antisocial personality disorder (OR=3.27), and suicidal ideation (OR=1.98) increased persistent polydrug use risk; depression (OR=2.38) and lifetime suicide attempt (OR=2.31) increased persistent prescription misuse risk. Relative to persistent prescription drug misuse, persistent polydrug use was associated with higher rates of cannabis and stimulant use disorder (OR=6.14–28.01), younger first substance use (OR=0.82–0.83), more drug use opportunity (OR=10.66–66.06), and more drug-using peers (OR=4.66–9.20). Unique patterns of desistant and persistent drug use are differentially heritable and differentially associated with risk factors, psychiatric symptoms, and substance use disorder outcomes.
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影响因子：
5.4
作者：
Bolck, A;Croon, M;Hagenaars, J
通讯作者：
Hagenaars, J
DOI：
10.1016/j.jpain.2009.07.016
发表时间：
2010-04
期刊：
The journal of pain
影响因子：
--
作者：
Jamison RN;Butler SF;Budman SH;Edwards RR;Wasan AD
通讯作者：
Wasan AD
影响因子：
5.3
作者：
Compton, WM;Conway, KP;Grant, BF
通讯作者：
Grant, BF
影响因子：
6
作者：
Degenhardt, L;Barker, B;Topp, L
通讯作者：
Topp, L
影响因子：
4.2
作者：
Green, Traci C.;Kershaw, Trace;Justice, Amy C.
通讯作者：
Justice, Amy C.