Overtone mobility spectrometry: part 1. Experimental observations.
Overtone mobility spectrometry: part 1. Experimental observations.
复制标题
DOI：
10.1016/j.jasms.2008.11.022
复制
发表时间：
2009-05
影响因子：
3.2
通讯作者：
Clemmer DE
中科院分区：
文献类型：
--
作者：
Kurulugama RT;Nachtigall FM;Lee S;Valentine SJ;Clemmer DE
本文介绍了一种使线性漂移管作为连续离子迁移率过滤器工作的新方法。与利用静电门将离子包引入漂移区的常规离子迁移率仪器不同，本方法使用具有调制漂移场的多个分段漂移区来产生仅允许具有适当迁移率的离子通过仪器的条件。通过这种方式，该仪器可作为连续离子源的迁移率过滤器。通过改变所施加的漂移场的频率，可以调谐该仪器以传输具有不同迁移率的离子。对单个离子种类在宽范围的漂移场频率上的扫描示出了对应于一个漂移区域段中的离子的预期谐振时间的峰值以及作为谐振频率的泛音的较高频率处的一系列峰值。所测量的分辨能力对于更高的泛音增加，使得能够分辨在基频区域中未分辨的结构。我们证明了这种方法，通过检查寡糖异构体，棉子糖和三糖，以及从肌红蛋白的酶消化获得的肽的混合物。
A new method that allows a linear drift tube to be operated as a continuous ion mobility filter is described. Unlike conventional ion mobility instruments that utilize an electrostatic gate to introduce a packet of ions into a drift region, the present approach uses multiple segmented drift regions with modulated drift fields to produce conditions that allow only ions with appropriate mobilities to pass through the instrument. In this way, the instrument acts as a mobility-filter for continuous ion sources. By changing the frequency of the applied drift fields it is possible to tune this instrument to transmit ions having different mobilities. A scan over a wide range of drift field frequencies for a single ion species shows a peak corresponding to the expected resonance time of the ions in one drift region segment and a series of peaks at higher frequencies that are overtones of the resonant frequency. The measured resolving power increases for higher overtones making it possible to resolve structures that were unresolved in the region of the fundamental frequency. We demonstrate the approach by examining oligosaccharide isomers, raffinose and melezitose as well as a mixture of peptides obtained from enzymatic digestion of myoglobin.
登录
查看更多内容
影响因子：
15
作者：
Mack, E
通讯作者：
Mack, E
影响因子：
6.2
作者：
Asbury, GR;Wu, C;Hill, HH
通讯作者：
Hill, HH
影响因子：
15
作者：
Hudgins, RR;Ratner, MA;Jarrold, MF
通讯作者：
Jarrold, MF
影响因子：
7.4
作者：
Hoaglund, CS;Valentine, SJ;Clemmer, DE
通讯作者：
Clemmer, DE
DOI：
10.1016/s1044-0305(01)00283-5
发表时间：
2001-09-01
影响因子：
3.2
作者：
Counterman, AE;Hilderbrand, AE;Clemmer, DE
通讯作者：
Clemmer, DE