Correlation of cutaneous immunoreactants in lesional skin with the serological disorders and disease activity of systemic lupus erythematosus.
Correlation of cutaneous immunoreactants in lesional skin with the serological disorders and disease activity of systemic lupus erythematosus.
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DOI：
10.1371/journal.pone.0070983
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Luo YJ;Tan GZ;Yu M;Li KW;Liu YY;Guo Q;Zeng FQ;Wang L
通过直接免疫荧光（DIF）从皮肤检测免疫反应物包括IgG、IgM、伊加和C3可用于区分狼疮病变与其他皮肤疾病。尽管其诊断价值，皮肤免疫反应物的类型和数量，因为它们涉及血清学疾病和疾病的严重程度一直研究甚少。我们检查了36例DIF阳性（DIF+）和28例DIF阴性（DIF−）的系统性狼疮性肾炎（SLE）患者的皮损皮肤试验。在DIF+患者中，最常见的免疫反应物模式是IgM单独（36%）和IgM与C3共存（28%）。IgM是检测到的最高的个体免疫反应物（86%）。按数量分类，36例DIF+患者中有17例有1种免疫反应物（= 1），而其余患者有2至4种免疫反应物（>1）。 与DIF−患者相比，DIF+患者更可能患有严重疾病，如血清C3水平较低和SLE疾病活动指数（SLEDAI）较高。IgM与任何其他免疫反应物的共存表明比DIF−组中存在的疾病更严重，而单独IgM组在血清C3水平和SLEDAI方面与DIF−组相当。这些发现也适用于比较具有多于一种（>1）免疫反应物的患者与无（DIF−）和一种（= 1）免疫反应物的患者。 总的来说，病变皮肤中存在多种免疫反应物意味着SLE的疾病活动性更严重，而单一免疫反应物在预测疾病活动性方面可能等同于缺乏免疫反应物（DIF−）。
Detection of immunoreactants including IgG, IgM, IgA, and C3 by direct immunofluorescence (DIF) from skin is useful for distinguishing lupus lesions from other skin disorders. Despite their diagnostic value, the type and number of cutaneous immunoreactants as they relate to serological disorders and disease severity has been poorly studied. We examined 36 patients with systemic lupus erythematosis (SLE) with positive DIF (DIF+) and 28 patients with negative DIF (DIF−) tests performed on lesional skin. Among DIF+ patients, the most frequent patterns of immunoreactants were IgM alone (36%) and the coexistence of IgM with C3 (28%). IgM was the highest detected individual immunoreactant (86%). As classified by number, 17 of 36 DIF+ patients had one immunoreactant ( = 1), while the remaining patients had two to four immunoreactants (>1). Compared with DIF− patients, DIF+ patients were more likely to have severe disease as indicated by lower serum C3 levels and a higher SLE disease activity index (SLEDAI). The coexistence of IgM with any other immunoreactants indicated a more severe disease than that present in the DIF− group, whereas the IgM-alone group was comparable with the DIF− group in both serum C3 levels and SLEDAI. These findings were also applicable in the comparison of patients with more than one (>1) immunoreactant and patients with no (DIF−) and one ( = 1) immunoreactant. Collectively, the presence of multiple immunoreactants in lesional skin implies a more severe disease activity of SLE, while a single immunoreactant may be equal to the absence of immunoreactants (DIF−) in terms of predicting disease activity.
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影响因子：
2.6
作者：
Cardinali, C;Caproni, M;Fabbri, P
通讯作者：
Fabbri, P
影响因子：
--
作者：
SMITH, CD;MARINO, C;ROTHFIELD, NF
通讯作者：
ROTHFIELD, NF
影响因子：
6.5
作者：
DAVIS, BM;GILLIAM, JN
通讯作者：
GILLIAM, JN
DOI：
10.1016/0090-1229(85)90047-9
发表时间：
1985-01-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
GABRIELLI, A;CORVETTA, A;DANIELI, G
通讯作者：
DANIELI, G
影响因子：
--
作者：
MORRIS, RJ;GUGGENHEIM, SJ;KOHLER, PF
通讯作者：
KOHLER, PF