From structure to application: Progress and opportunities in peptide materials development.
From structure to application: Progress and opportunities in peptide materials development.
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DOI：
10.1016/j.cbpa.2021.06.006
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发表时间：
2021-10
影响因子：
7.8
通讯作者：
Schneider JP
中科院分区：
文献类型：
--
作者：
Lopez-Silva TL;Schneider JP
20多年来，水凝胶或可溶性原纤维形式的肽材料已用于生物医学应用，例如药物递送、细胞培养、疫苗和组织再生。为便于翻译这些材料，仍需解决关键的研究领域。与淀粉样蛋白相比，它们的结构特征滞后。许多设计用于引导材料形成的结构特征主要通过它们在淀粉样蛋白组装体的原子分辨率结构中的观察来表征。在本文中，这些基序与肽设计相关地被检查，以识别驱动组装并提供结构特异性的共同相互作用。目前的努力，设计复杂的结构，如本文所述，强调需要扩展淀粉样蛋白的结构革命肽组件，以验证设计原则。关于临床应用，蛋白质、细胞和免疫系统对肽材料的基本相互作用和反应仍然没有很好地理解。只有少数趋势是刚刚出现的肽材料与生物系统的相互作用。了解肽材料特性如何影响这些相互作用将使材料能够向当前和新兴应用转化。
For over 20 years, peptide materials in their hydrogel or soluble fibril form have been used for biomedical applications such as drug delivery, cell culture, vaccines, and tissue regeneration. To facilitate the translation of these materials, key areas of research still need to be addressed. Their structural characterization lags compared to amyloid proteins. Many of the structural features designed to guide materials formation are primarily being characterized by their observation in atomic resolution structures of amyloid assemblies. Herein, these motifs are examined in relation to peptide designs identifying common interactions that drive assembly and provide structural specificity. Current efforts to design complex structures, as reviewed here, highlight the need to extend the structural revolution of amyloid proteins to peptide assemblies to validate design principles. With respect to clinical applications, the fundamental interactions and responses of proteins, cells, and the immune system to peptide materials are still not well understood. Only a few trends are just now emerging for peptide materials interactions with biological systems. Understanding how peptide material properties influence these interactions will enable the translation of materials towards current and emerging applications.
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DOI：
10.1016/j.matbio.2019.06.009
发表时间：
2020-01
期刊：
Matrix biology : journal of the International Society for Matrix Biology
影响因子：
--
作者：
Ashworth JC;Thompson JL;James JR;Slater CE;Pijuan-Galitó S;Lis-Slimak K;Holley RJ;Meade KA;Thompson A;Arkill KP;Tassieri M;Wright AJ;Farnie G;Merry CLR
通讯作者：
Merry CLR
影响因子：
16.8
作者：
Cao, Qin;Boyer, David R.;Eisenberg, David S.
通讯作者：
Eisenberg, David S.
影响因子：
62.1
作者：
Du X;Zhou J;Shi J;Xu B
通讯作者：
Xu B
用于加速伤口愈合的仿生纳米纤维糖肽水凝胶敷料：一种无细胞因子的 M2 型巨噬细胞极化方法
影响因子：
19
作者：
Feng, Zujian;Su, Qi;Wang, Weiwei
通讯作者：
Wang, Weiwei
影响因子：
14.8
作者：
Bieschke, Jan;Herbst, Martin;Wanker, Erich E.
通讯作者：
Wanker, Erich E.