A systematic review and meta-analysis of the prevalence of human cytomegalovirus shedding in seropositive pregnant women.
A systematic review and meta-analysis of the prevalence of human cytomegalovirus shedding in seropositive pregnant women.
复制标题
DOI：
10.1002/rmv.2399
复制
发表时间：
2022-11
影响因子：
11.1
通讯作者：
Jones, Christine E.
中科院分区：
文献类型：
--
作者：
Sapuan, Shari;Theodosiou, Anastasia A.;Strang, Blair L.;Heath, Paul T.;Jones, Christine E.
通过培养技术或通过聚合酶链反应检测个体体液中的人巨细胞病毒（HCMV）DNA，被称为HCMV脱落。人巨细胞病毒脱落具有传播HCMV感染的潜力，其中个体可以通过接触另一个含有HCMV的个体的体液而感染HCMV。人巨细胞病毒脱落可发生在原发性感染和既往感染（HCMV血清阳性）个体的非原发性感染中。人巨细胞病毒感染在孕妇中引起很少或没有症状，但如果发生先天性CMV（cCMV）感染，则可能对胎儿造成重大伤害。HCMV血清阳性孕妇中HCMV脱落与HCMV垂直传播导致cCMV感染之间的相关性研究不足，对HCMV血清阳性孕妇中HCMV脱落分布的了解有限。我们系统地回顾了已发表的文献，以描述HCMV血清阳性妇女在妊娠至分娩期间HCMV脱落的患病率。这项分析确定了9项符合我们资格标准的研究。在这些研究中，妊娠期间和分娩时HCMV血清阳性女性的任何体液中HCMV脱落的患病率范围为0%至42.5%。对9项研究中的6项进行了Meta分析，采用适当的样本量，估计合并患病率为21.5% [95% CI 12.7%，30.3%]。据我们所知，这是第一次系统地检索文献，总结HCMV血清阳性孕妇的HCMV脱落的患病率。这些估计值有助于在非原发性母体HCMV感染的背景下开发疾病负担模型和针对cCMV感染的治疗或预防策略。
The detection of human cytomegalovirus (HCMV) in an individual's bodily fluid by culture techniques or through HCMV DNA detection by polymerase chain reaction, is known as HCMV shedding. Human cytomegalovirus shedding has the potential to transmit HCMV infection, where an individual can become infected with HCMV through contact with the bodily fluid of another individual containing HCMV. Human cytomegalovirus shedding can occur in primary infection and in non‐primary infection for individuals with prior infection (HCMV seropositive). Human cytomegalovirus infection causes few or no symptoms in a pregnant woman, but can cause significant harm to her foetus if congenital CMV (cCMV) infection occurs. The association between HCMV shedding in HCMV seropositive pregnant women and the vertical transmission of HCMV to result in cCMV infection is poorly investigated, challenged by a limited understanding of the distribution of HCMV shedding in HCMV seropositive pregnant women. We systematically reviewed the published literature to describe the prevalence of HCMV shedding in HCMV seropositive women during pregnancy up to delivery. This analysis identified nine studies that met our eligibility criteria. In these studies, the prevalence of HCMV shedding in any bodily fluid of HCMV seropositive women during pregnancy and at delivery ranged from 0% to 42.5%. A meta‐analysis, performed on six of the nine studies with suitable sample sizes, estimated a pooled prevalence of 21.5% [95% CI 12.7%,30.3%]. To our knowledge, this is the first review to systematically search the literature to summarise the prevalence of HCMV shedding in HCMV seropositive pregnant women. These estimates can help in the development of disease burden models and therapeutic or preventative strategies against cCMV infection in the context of non‐primary maternal HCMV infection.
登录
查看更多内容
影响因子：
1.8
作者：
Neyeloff JL;Fuchs SC;Moreira LB
通讯作者：
Moreira LB
影响因子：
6.4
作者：
GEHRZ, RC;CHRISTIANSON, WR;BALFOUR, HH
通讯作者：
BALFOUR, HH
DOI：
10.1111/j.1471-0528.1991.tb13358.x
发表时间：
1991-02-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
GRIFFITHS, PD;BABOONIAN, C;PECKHAM, C
通讯作者：
PECKHAM, C
DOI：
10.1016/0301-2115(95)02541-3
发表时间：
1996-11-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Kyriazopoulou, V;Bondis, J;Souliou, E
通讯作者：
Souliou, E
影响因子：
12.7
作者：
Fujikawa, T;Numazaki, K;Tsutsumi, H
通讯作者：
Tsutsumi, H