Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.
Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.
复制标题
评估母亲患注意缺陷多动障碍的风险与其亲生幼儿大脑功能连接之间的关系。
DOI：
10.1192/j.eurpsy.2022.2325
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发表时间：
2022-10-13
影响因子：
7.8
通讯作者：
Doucet, Gaelle E.
中科院分区：
文献类型：
--
作者：
Kerr-German, Anastasia;White, Stuart F.;Santosa, Hendrik;Buss, Aaron T.;Doucet, Gaelle E.
注意力缺陷多动障碍(ADHD)是一种神经发育障碍，与教育程度低和社会融合受损的风险增加有关。目前，临床诊断很少在学龄前进行，尽管儿童很早就有ADHD的行为迹象。目前还没有已知的2-3岁儿童ADHD风险的脑生物标志物。本研究旨在通过双侧额叶和顶叶皮质的功能近红外光谱(FNIRS)，研究70名2.5岁和3.5岁的儿童的功能连通性(FC)与ADHD风险的关系。这些区域涉及注意力和目标定向认知。孩子们被指示被动观看视频约5分钟。通过ADHD的母亲症状评估每个儿童患ADHD的风险，并评估大脑数据中的FC。母亲ADHD的风险较高与左侧顶额叶网络中的FC较低相关。此外，性别和ADHD风险之间的交互作用是显著的，在广泛的双侧顶额叶网络中，FC降低与男性参与者更高的风险相关，而女性参与者则不是。这些发现表明，有ADHD风险的幼儿在顶额叶网络中的功能组织存在差异；这可能会促进人们对ADHD发生的神经机制的理解。
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with increased risk for poor educational attainment and compromised social integration. Currently, clinical diagnosis rarely occurs before school-age, despite behavioral signs of ADHD in very early childhood. There is no known brain biomarker for ADHD risk in children ages 2–3 years-old. The current study aimed to investigate the functional connectivity (FC) associated with ADHD risk in 70 children aged 2.5 and 3.5 years via functional near-infrared spectroscopy (fNIRS) in bilateral frontal and parietal cortices; regions involved in attentional and goal-directed cognition. Children were instructed to passively watch videos for approximately 5 min. Risk for ADHD in each child was assessed via maternal symptoms of ADHD, and brain data was evaluated for FC. Higher risk for maternal ADHD was associated with lower FC in a left-sided parieto-frontal network. Further, the interaction between sex and risk for ADHD was significant, where FC reduction in a widespread bilateral parieto-frontal network was associated with higher risk in male, but not female, participants. These findings suggest functional organization differences in the parietal–frontal network in toddlers at risk for ADHD; potentially advancing the understanding of the neural mechanisms underlying the development of ADHD.
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DOI：
10.1111/j.1469-7610.2007.01811.x
发表时间：
2007-10-01
影响因子：
7.6
作者：
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影响因子：
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DOI：
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DOI：
10.1080/15374416.2017.1417860
发表时间：
2018-03
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
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作者：
Danielson ML;Bitsko RH;Ghandour RM;Holbrook JR;Kogan MD;Blumberg SJ
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Blumberg SJ