A review of low-intensity ultrasound for cancer therapy.

A review of low-intensity ultrasound for cancer therapy.
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DOI:
10.1016/j.ultrasmedbio.2014.11.019
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发表时间:
2015-04
影响因子:
2.9
通讯作者:
Sehgal, Chandra M.
Sehgal, Chandra M.
中科院分区:
医学3区
文献类型:
--
作者:
Wood, Andrew K. W.;Sehgal, Chandra M.

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The literature describing the use of low-intensity ultrasound in four major areas of cancer therapy was reviewed - sonodynamic therapy, ultrasound mediated chemotherapy, ultrasound mediated gene delivery and antivascular ultrasound therapy. Each technique consistently resulted in the death of cancer cells and the bioeffects of ultrasound were primarily attributed to thermal actions and inertial cavitation. In each therapeutic modality, theranostic contrast agents composed of microbubbles played a role in both therapy and vascular imaging. The development of these agents is important as it establishes a therapeutic-diagnostic platform which can monitor the success of anti-cancer therapy. Little attention, however, has been given to either the direct assessment of the underlying mechanisms of the observed bioeffects or to the viability of these therapies in naturally occurring cancers in larger mammals; if such investigations provided encouraging data there could be a prompt application of a therapy technique in treating cancer patients.
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