Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error monitoring.
Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error monitoring.
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DOI：
10.1111/psyp.13794
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发表时间：
2021-05
期刊：
影响因子：
3.7
通讯作者：
Carlson JM
中科院分区：
文献类型：
--
作者：
Gilbertson H;Fang L;Andrzejewski JA;Carlson JM
错误相关负波（ERN）是一种反应锁定事件相关电位，发生在额中央电极部位错误反应后约50 ms。源定位和功能性磁共振成像（fMRI）研究表明，ERN可能是由背侧前扣带皮层（dACC）的活动产生的。dACC被认为是更广泛的大脑区域网络的一部分，这些区域共同组成了一个错误监控网络。然而，关于基于dACC的错误监控网络内的内在连接如何有助于ERN振幅的变化，人们知之甚少。本研究的目的是评估dACC功能连接和ERN振幅之间的关系。在高度特质焦虑个体的样本中，ERN在侧翼任务中被引出，功能连接在10分钟的静息状态fMRI扫描中被评估。结果表明，dACC与辅助运动区的功能连接的强度与ΔERN相关（即，不正确-正确反应）振幅，使得更大的ΔERN振幅伴随着这些区域之间更大的功能耦合。总之，ERN振幅似乎与大脑的错误监控和运动控制区域之间的功能连接强度有关。
The error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.
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