Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.
Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain.
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DOI：
10.1111/j.1460-9568.2012.08119.x
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Price DJ
中科院分区：
文献类型：
--
作者：
Molnár Z;Garel S;López-Bendito G;Maness P;Price DJ
丘脑皮质轴突必须穿过一个复杂的细胞地形，穿过发育中的前脑，我们必须了解这个地形，才能了解丘脑皮质轴突如何到达目的地。选择性肌束震颤、路标细胞、各种间脑和端脑梯度都与丘脑皮质的引导有关。随着我们对相关前脑模式的理解的增加，我们对指导机制的了解也在增加。我们在这里的目的是审查最近的观察有关的细胞和分子机制：丘脑离体投射腹侧端脑的增长，丘脑轴突避免下丘脑和延伸到端脑形成内囊，交叉的苍白球-苍白球下边界和向大脑皮层的增长。我们将回顾目前的理论解释的维持和改变地形秩序的丘脑皮质投射到皮层。现在越来越清楚的是，在丘脑皮质发育的不同阶段涉及到几种机制，每一种机制都对最终的结果有很大的贡献。揭示分子和细胞机制有助于将特定基因与实际发育机制的细节联系起来。
Thalamocortical axons must cross a complex cellular terrain through the developing forebrain and this terrain has to be understood for us to learn how thalamocortical axons reach their destinations. Selective fasciculation, guidepost cells, various diencephalic and telencephalic gradients have been implicated in thalamocortical guidance. As our understanding of the relevant forebrain patterns has increased, so has out knowledge of the guidance mechanisms. Our aim here is to review recent observations of cellular and molecular mechanisms relating to: the growth of thalamofugal projections to the ventral telencephalon, thalamic axon avoidance of the hypothalamus and extension into the telencephalon to form the internal capsule, the crossing of the pallial-subpallial boundary and the growth towards the cerebral cortex. We shall review current theories for the explanation of the maintenance and alteration of topographic order in the thalamocortical projections to the cortex. It is now increasingly clear that several mechanisms are involved at different stages of thalamocortical development and each contributes substantially to the eventual outcome. Revealing the molecular and cellular mechanisms can help to link specific genes to details of actual developmental mechanisms.
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影响因子：
4.6
作者：
Andrews, William;Liapi, Anastasia;Richards, Linda J.
通讯作者：
Richards, Linda J.
影响因子：
2.5
作者：
ADAMS, NC;BAKER, GE
通讯作者：
BAKER, GE
DOI：
10.1093/cercor/bhp035
发表时间：
2009-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Braisted JE;Ringstedt T;O'Leary DD
通讯作者：
O'Leary DD
DOI：
10.1073/pnas.88.8.2999
发表时间：
1991-04-01
影响因子：
11.1
作者：
CATALANO, SM;ROBERTSON, RT;KILLACKEY, HP
通讯作者：
KILLACKEY, HP
影响因子：
16.2
作者：
Castellani, V;Chédotal, A;Rougon, G
通讯作者：
Rougon, G