Serum Galectin-3 level, not Galectin-1, is associated with the clinical feature and outcome in patients with acute ischemic stroke.
Serum Galectin-3 level, not Galectin-1, is associated with the clinical feature and outcome in patients with acute ischemic stroke.
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DOI：
10.18632/oncotarget.18211
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发表时间：
2017-12-12
期刊：
影响因子：
--
通讯作者：
Liu SY
中科院分区：
文献类型：
--
作者：
Dong H;Wang ZH;Zhang N;Liu SD;Zhao JJ;Liu SY
目的探讨血清半乳糖凝集素-1（Gal-1）和-3（Gal-3）在急性缺血性脑卒中（AIS）诊断和预后中的作用。在这项研究中，我们招募了233名首次急性缺血性卒中患者和252名健康对照者。采用美国国立卫生研究院卒中量表（NIHSS）评分评估AIS严重程度。测定血清Gal-1和Gal-3水平。所有患者随访1年，采用改良兰金量表（mRS）评分评价功能结局。我们发现AIS患者血清Gal-1和Gal-3水平高于对照组。血清Gal-3水平与AIS严重程度及梗死体积密切相关。mRS评分显示预后不良的患者血清Gal-3水平显著高于预后良好的患者。相反，血清Gal-1与急性AIS患者的严重程度和结局无关。我们的体外研究表明，Gal-3敲低siRNA显着增加培养神经元细胞的活力和减少细胞凋亡的氧葡萄糖剥夺治疗。同时，促炎细胞因子的表达随着Gal-3的抑制而降低。我们的发现为急性AIS患者的监测提供了一种新型生物标志物--血清Gal-3。
To study the diagnostic and prognostic role of serum galectin-1 (Gal-1) and -3 (Gal-3) in acute ischemic stroke (AIS) patients. We enrolled 233 patients with first-ever acute ischemic stroke and 252 healthy controls in this study. The AIS severity was evaluated by National Institutes of Health Stroke Scale (NIHSS) scores. The serum Gal-1 and -3 levels were determined. All patients were followed for 1 years and the functional outcome were evaluated by modified Rankin Scale (mRS) scores. We found that AIS patients had higher serum Gal-1 and -3 levels than controls. The serum Gal-3 level was closely associated with the AIS severity indicated by NHSS and infarction volume. Serum Gal-3 levels were significantly higher in patients with a poor outcome indicated by mRS scores than those in patients with a good outcome. In contrast, the serum Gal-1 is not associated with the severity and outcome of acute AIS patients. Our in vitro studies show that Gal-3 knockdown with siRNA dramatically increased the culture neuron cell viability and reduced apoptosis under oxygen glucose deprivation treatment. Meanwhile, the pro-inflammatory cytokine expression decreased with the inhibition of Gal-3. Our finding provides a novel biological marker, serum Gal-3, for monitor of acute AIS patients.
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DOI：
10.1016/s1052-3057(03)00042-9
发表时间：
2003-05-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Kelly-Hayes, Margaret;Beiser, Alexa;Wolf, Philip A
通讯作者：
Wolf, Philip A
DOI：
10.1016/j.mcn.2014.12.006
发表时间：
2015-01
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Gaudet AD;Sweet DR;Polinski NK;Guan Z;Popovich PG
通讯作者：
Popovich PG
影响因子：
2.5
作者：
Compagno, D.;Jaworski, F. M.;Laderach, D. J.
通讯作者：
Laderach, D. J.
Galectin-1 增强星形胶质细胞 BDNF 的产生并改善缺血后大鼠的功能结果
影响因子：
4.4
作者：
Qu, Wen-sheng;Wang, Yi-hui;Wang, Wei
通讯作者：
Wang, Wei
影响因子：
5.7
作者：
Cheong, Teak-Chin;Shin, Ji-Young;Chun, Kyung-Hee
通讯作者：
Chun, Kyung-Hee