Serum Insulin-Like Growth Factor Binding Protein 7 as a Potential Biomarker in the Diagnosis and Prognosis of Esophagogastric Junction Adenocarcinoma.
Serum Insulin-Like Growth Factor Binding Protein 7 as a Potential Biomarker in the Diagnosis and Prognosis of Esophagogastric Junction Adenocarcinoma.
复制标题
血清胰岛素样生长因子结合蛋白7作为食管胃结合部腺癌诊断和预后的潜在生物标志物
DOI：
10.5009/gnl19135
复制
发表时间：
2020-11-15
期刊：
影响因子：
3.4
通讯作者：
Peng YH
中科院分区：
文献类型：
--
作者：
Liu CT;Xu YW;Guo H;Hong CQ;Huang XY;Luo YH;Yang SH;Chu LY;Li EM;Peng YH
食管胃交界腺癌（EJA）是一种高发病率的恶性肿瘤，因其发病率高、生存率低而越来越受到人们的关注。病理活检是诊断的金标准，但缺乏无创和有效的检查，导致晚期诊断。本研究探讨胰岛素样生长因子结合蛋白7 （IGFBP7）在EJA中的诊断价值。共招募120例EJA患者和88例正常对照，采用酶联免疫吸附法测定血清IGFBP7水平。采用受试者工作特征（ROC）曲线分析评估诊断价值，Pearson卡方分析评估IGFBP7与临床参数的相关性。采用Kaplan-Meier生存分析评估IGFBP7对总生存期（OS）的影响。早期和晚期EJA患者的IGFBP7水平均高于正常对照组（p<0.001）。EJA患者的ROC曲线下面积为0.794(95%可信区间[CI]， 0.733 ~ 0.854)，截止值为2.716 ng/mL，敏感性为63.3% (95% CI, 54.0% ~ 71.8%)，特异性为90.9% （95% CI, 82.4% ~ 95.7%）。对于早期EJA的诊断，获得了相同的截止值和特异性，但IGFBP7的敏感性为54.3% （95% CI, 36.9% ~ 70.8%）。IGFBP7蛋白低表达患者的OS低于高表达患者（p=0.034）。多因素分析显示IGFBP7是EJA的独立预后因素（p=0.011）。血清IGFBP7可作为EJA的潜在诊断和预后指标。
Esophagogastric junction adenocarcinoma (EJA) is a malignant tumor associated with high morbidity and has attracted increasing attention due to a rising incidence and low survival rate. Pathological biopsy is the gold standard for diagnosis, but noninvasive and effective tests are lacking, resulting in diagnoses at advanced stages. This study explored the diagnostic value of insulin-like growth factor binding protein 7 (IGFBP7) in EJA. A total of 120 EJA patients and 88 normal controls were recruited, and their serum levels of IGFBP7 were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic value, and Pearson chi-square analysis was used to evaluate the correlation between IGFBP7 and clinical parameters. Kaplan-Meier survival analysis was carried out to assess the effect of IGFBP7 on overall survival (OS). The levels of IGFBP7 were higher in both early- and late-stage EJA patients than in normal controls (p<0.001). The area under the ROC curve for EJA patients was 0.794 (95% confidence interval [CI], 0.733 to 0.854), with a cutoff value of 2.716 ng/mL, a sensitivity of 63.3% (95% CI, 54.0% to 71.8%) and a specificity of 90.9% (95% CI, 82.4% to 95.7%). For the diagnosis of early-stage EJA, the same cutoff value and specificity were obtained, but the sensitivity of IGFBP7 was 54.3% (95% CI, 36.9% to 70.8%). Patients with low IGFBP7 protein expression had lower OS than those with high expression (p=0.034). The multivariate analysis showed that IGFBP7 is an independent prognostic factor for EJA (p=0.011). Serum IGFBP7 acts as a potential diagnostic and prognostic marker for EJA.
登录
查看更多内容
DOI：
10.2147/copd.s132652
发表时间：
2017
影响因子：
2.8
作者：
Ruan W;Wu M;Shi L;Li F;Dong L;Qiu Y;Wu X;Ying K
通讯作者：
Ying K
DOI：
10.1073/pnas.94.24.12981
发表时间：
1997-11-25
影响因子：
11.1
作者：
Kim, HS;Nagalla, SR;Rosenfeld, RG
通讯作者：
Rosenfeld, RG
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ
中国人群血清 IGFBP7 水平与胰岛素抵抗和代谢综合征风险相关
影响因子：
4.6
作者：
Liu Y;Wu M;Ling J;Cai L;Zhang D;Gu HF;Wang H;Zhu Y;Lai M
通讯作者：
Lai M
影响因子：
4.8
作者：
Oh, YM;Nagalla, SR;Rosenfeld, RG
通讯作者：
Rosenfeld, RG