Macroporous scaffolds associated with cells to construct a hybrid biomaterial for bone tissue engineering
Macroporous scaffolds associated with cells to construct a hybrid biomaterial for bone tissue engineering
复制标题
与细胞相关的大孔支架构建用于骨组织工程的混合生物材料
DOI：
10.1586/17434440.5.6.719
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发表时间：
2008
影响因子：
3.1
通讯作者：
M. Beloti
中科院分区：
文献类型：
--
作者：
A. Rosa;P. D. de Oliveira;M. Beloti
骨组织具有愈合无疤痕和重塑的能力，这促进了三个基本功能：运动，保护内部器官和矿物质稳态。虽然骨再生是非常有效的，但在一些临床情况下，如较大的骨缺损，需要特殊的治疗来促进骨愈合。同种异体或自体骨移植已被用于这些手术，但成功率有限，基于此，骨组织工程方法已被广泛研究。组织工程被定义为应用生命科学和工程的原理和技术，使用生物材料、细胞和生长因子单独或组合来设计、修饰和生长活组织。将细胞与多孔支架结合，制备三维复合成骨结构是骨组织工程研究的一个常见课题，也是本文的重点。我们将介绍骨生物学的一些方面，用于工程骨的细胞和支架，以及制造混合生物材料的技术。
Bone tissue has the ability to heal without a scar and to remodel, which promotes three basic functions: locomotion, protection of internal organs and mineral homeostasis. Although bone regeneration is highly efficient, some clinical situations – such as large bone defects – require specific treatments in order to promote bone healing. Allogenic or autologous bone grafts have been used in these procedures with limited success and, based on this, bone tissue-engineering approaches have been investigated extensively. Tissue engineering has been defined as the application of principles and techniques of the life sciences and engineering to the design, modification and growth of living tissues using biomaterials, cells and growth factors, alone or in combination. The association of cells with porous scaffolds to produce 3D hybrid osteogenic constructs is a common subject in bone tissue-engineering research and will be the focus of this review. We will present some aspects of bone biology, the cells and scaffolds used to engineer bone, and techniques to fabricate the hybrid biomaterial.
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DOI：
10.1002/jbm.10150
发表时间：
2002-10-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Sikavitsas, VI;Bancroft, GN;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
14
作者：
Ishaug-Riley, SL;Crane-Kruger, GM;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
14
作者：
Goldstein, AS;Juarez, TM;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
--
作者：
J. Lian;G. Stein
通讯作者：
J. Lian;G. Stein
影响因子：
14
作者：
Yao, J;Radin, S;Ducheyne, P
通讯作者：
Ducheyne, P