Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: a functional connectivity MRI study.
Repetitive behaviors in autism are linked to imbalance of corticostriatal connectivity: a functional connectivity MRI study.
复制标题
DOI：
10.1093/scan/nsx129
复制
发表时间：
2018-01-01
影响因子：
4.2
通讯作者：
Müller RA
中科院分区：
文献类型：
--
作者：
Abbott AE;Linke AC;Nair A;Jahedi A;Alba LA;Keown CL;Fishman I;Müller RA
自闭症谱系障碍（ASD）中重复行为（RB）的神经基础，从认知到运动特征，仍然未知。我们评估了50名ASD和52名典型发育（TD）儿童和青少年（年龄8-17岁）的RB神经病学，检查皮质纹状体回路的内在功能连接（iFC），这对于基于奖励的学习和情感，认知和运动处理的整合非常重要，并被认为在ASD中受损。三个功能不同的纹状体种子（边缘，额顶叶和电机）进行连接分析。皮质纹状体回路连接指数和比率评估了与感兴趣的皮质区域的功能连接，测试回路之间的连接平衡。结果表明，皮质纹状体的边缘和额顶种子连接过度，但运动种子连接不足。与RB的相关性被发现从全脑分析的纹状体运动种子和皮质运动集群之间的连接，以及额顶叶/边缘和电机/边缘连接比率。将ASD参与者分为高RB（n = 17）和低RB亚组（n = 19），与低RB和TD组相比，右半球高RB组的额顶/边缘和运动/边缘回路比率降低。结果表明，RB和ASD皮质纹状体iFC的不平衡之间的关联，增加边缘系统，但减少额顶叶和运动电路。
The neural underpinnings of repetitive behaviors (RBs) in autism spectrum disorders (ASDs), ranging from cognitive to motor characteristics, remain unknown. We assessed RB symptomatology in 50 ASD and 52 typically developing (TD) children and adolescents (ages 8–17 years), examining intrinsic functional connectivity (iFC) of corticostriatal circuitry, which is important for reward-based learning and integration of emotional, cognitive and motor processing, and considered impaired in ASDs. Connectivity analyses were performed for three functionally distinct striatal seeds (limbic, frontoparietal and motor). Functional connectivity with cortical regions of interest was assessed for corticostriatal circuit connectivity indices and ratios, testing the balance of connectivity between circuits. Results showed corticostriatal overconnectivity of limbic and frontoparietal seeds, but underconnectivity of motor seeds. Correlations with RBs were found for connectivity between the striatal motor seeds and cortical motor clusters from the whole-brain analysis, and for frontoparietal/limbic and motor/limbic connectivity ratios. Division of ASD participants into high (n = 17) and low RB subgroups (n = 19) showed reduced frontoparietal/limbic and motor/limbic circuit ratios for high RB compared to low RB and TD groups in the right hemisphere. Results suggest an association between RBs and an imbalance of corticostriatal iFC in ASD, being increased for limbic, but reduced for frontoparietal and motor circuits.
登录
查看更多内容
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
3.9
作者：
Esbensen, Anna J.;Seltzer, Marsha Mailick;Bodfish, James W.
通讯作者：
Bodfish, James W.
影响因子：
4.7
作者：
Estes, Annette;Shaw, Dennis W. W.;Sparks, Bobbi F.;Friedman, Seth;Giedd, Jay N.;Dawson, Geraldine;Bryan, Matthew;Dager, Stephen R.
通讯作者：
Dager, Stephen R.
影响因子：
6.8
作者：
D'Cruz AM;Mosconi MW;Ragozzino ME;Cook EH;Sweeney JA
通讯作者：
Sweeney JA
影响因子：
10.6
作者：
Di Martino, Adriana;Kelly, Clare;Grzadzinski, Rebecca;Zuo, Xi-Nian;Mennes, Maarten;Angeles Mairena, Maria;Lord, Catherine;Castellanos, F. Xavier;Milham, Michael P.
通讯作者：
Milham, Michael P.