Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder.
Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder.
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DOI：
10.1002/aur.193
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发表时间：
2011-06
期刊：
影响因子：
4.7
通讯作者：
Dager, Stephen R.
中科院分区：
文献类型：
--
作者：
Estes, Annette;Shaw, Dennis W. W.;Sparks, Bobbi F.;Friedman, Seth;Giedd, Jay N.;Dawson, Geraldine;Bryan, Matthew;Dager, Stephen R.
关键词：
我们研究了3-4岁自闭症谱系障碍(ASD；n=77)和非自闭症发育迟缓(DD；n=34)儿童的重复和刻板行为(RSB)及其与基底节和丘脑形态测量的关系。通过临床评估和家长报告，使用从自闭症诊断观察表(ADOS)、自闭症诊断访谈和异常行为检查表中提取的RSB特定量表对儿童进行评估。对45例ASD患儿、14例DD患儿和25例发育正常的患儿进行了磁共振成像(MRI)检查。与DD儿童相比，ASD儿童在所有指标上均表现出RSB升高。与TD组相比，ASD组左侧和右侧纹状体，更具体地说左侧和右侧壳核以及左侧尾状核增大。然而，在控制脑体积后，核团并没有明显增大。与ASD组相比，DD组的丘脑和基底节区域较小，但左侧纹状体、左侧壳核和右侧壳核除外。ADOS测量的RSB升高与ASD组的几个脑区：左侧丘脑、右侧苍白球、左右壳核、右侧纹状体以及左侧苍白球和左侧纹状体的体积下降有关。这些结果证实了早期的报道，即RSB在ASD的临床病程早期是常见的，并进一步表明这种行为可能与基底节和丘脑的体积减少有关。
We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3-4 year old children with autism spectrum disorder (ASD; n=77) and developmental delay without autism (DD; n=34). Children were assessed through clinical evaluation and parent report using RSB-specific scales extracted from the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview, and the Aberrant Behavior Checklist. A subset of children with ASD (n=45), DD (n=14) and a group of children with typical development (TD; n=25) were also assessed by magnetic resonance imaging (MRI). Children with ASD demonstrated elevated RSB across all measures compared to children with DD. Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group. However, nuclei were not significantly enlarged after controlling for cerebral volume. The DD group, in comparison to the ASD group, demonstrated smaller thalami and basal ganglia regions even when scaled for cerebral volume, with the exception of the left striatum, left putamen, and right putamen. Elevated RSB, as measured by the ADOS, was associated with decreased volumes in several brain regions: left thalamus, right globus pallidus, left and right putamen, right striatum and a trend for left globus pallidus and left striatum within the ASD group. These results confirm earlier reports that RSB is common early in the clinical course of ASD and, furthermore, demonstrate that such behaviors may be associated with decreased volumes of the basal ganglia and thalamus.
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影响因子：
17.7
作者：
Hwang, J;Lyoo, IK;Renshaw, PF
通讯作者：
Renshaw, PF
DOI：
10.1111/j.1469-7610.2008.01904.x
发表时间：
2008-08-01
影响因子：
7.6
作者：
Morgan, Lindee;Wetherby, Amy M.;Barber, Angie
通讯作者：
Barber, Angie
影响因子：
10.6
作者：
Langen, Marieke;Durston, Sarah;van Engeland, Herman
通讯作者：
van Engeland, Herman
影响因子：
3.9
作者：
Richler, Jennifer;Bishop, Somer L.;Lord, Catherine
通讯作者：
Lord, Catherine
影响因子：
2.9
作者：
Cuccaro, ML;Shao, YJ;Pericak-Vance, MA
通讯作者：
Pericak-Vance, MA