Aberrant striatal functional connectivity in children with autism.
Aberrant striatal functional connectivity in children with autism.
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DOI：
10.1016/j.biopsych.2010.10.029
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发表时间：
2011-05-01
影响因子：
10.6
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Di Martino, Adriana;Kelly, Clare;Grzadzinski, Rebecca;Zuo, Xi-Nian;Mennes, Maarten;Angeles Mairena, Maria;Lord, Catherine;Castellanos, F. Xavier;Milham, Michael P.
自闭症谱系障碍（ASD）作为神经连接障碍综合征的模型主要得到自闭症成人皮质-皮质网络异常检查的支持。更广泛的研究表明，皮质下结构，特别是纹状体，与自闭症的病理生理学有关。静息状态功能磁共振成像揭示了健康和精神病人群的纹状体回路的详细地图，并生动地捕捉到了典型发育过程中纹状体回路的成熟变化。使用静息状态功能磁共振成像，我们研究了20名ASD儿童和20名年龄在7.6至13.5岁之间的典型发育儿童（TDC）的纹状体功能连接。全脑体素明智的统计地图量化组内纹状体FC和组间差异的三个尾状核和三个壳核种子，每个半球。ASD儿童大多表现出异位纹状体功能连接的突出模式（即，ASD中存在但TDC中不存在的功能连接性），几乎所有纹状体亚区与先前在ASD的生理病理学中涉及的异模态联合和边缘皮质之间的功能连接性增加（例如，岛叶和右上级颞回）。此外，我们发现纹状体与脑桥的功能超连通性，从而扩大了ASD所涉及的功能改变的范围。二次分析显示脑桥和岛叶皮质之间存在ASD相关的超连通性。对ASD儿童纹状体网络功能连接的检查显示，涉及早期发育区域（如脑干和小脑）的回路异常，异位回路中功能连接增加的模式可能反映了功能回路的发育紊乱，而不是不成熟。
Models of Autism Spectrum Disorders (ASD) as neural dysconnection syndromes have been predominantly supported by examinations of abnormalities in cortico-cortical networks in adults with autism. A broader body of research implicates subcortical structures, particularly the striatum, in the physiopathology of autism. Resting state fMRI has revealed detailed maps of striatal circuitry in healthy and psychiatric populations, and vividly captured maturational changes in striatal circuitry during typical development. Using resting state fMRI, we examined striatal functional connectivity in 20 children with ASD and 20 typically developing children (TDC) between the age of 7.6 and 13.5 years. Whole-brain voxel-wise statistical maps quantified within-group striatal FC and between-group differences for three caudate and three putamen seeds, for each hemisphere. Children with ASD mostly exhibited prominent patterns of ectopic striatal functional connectivity (i.e., functional connectivity present in ASD but not in TDC), with increased functional connectivity between nearly all striatal subregions and heteromodal associative and limbic cortex previously implicated in the physiopathology of ASD (e.g., insular and right superior temporal gyrus). Additionally, we found striatal functional hyperconnectivity with the pons, thus expanding the scope of functional alterations implicated in ASD. Secondary analyses revealed ASD-related hyperconnectivity between the pons and insular cortex. Examination of functional connectivity of striatal networks in children with ASD revealed abnormalities in circuits involving early developing areas such as the brainstem and insula, with a pattern of increased functional connectivity in ectopic circuits that likely reflects developmental derangement rather than immaturity of functional circuits.
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自闭症诊断观察表： 提高诊断有效性的修订算法
影响因子：
3.9
作者：
Gotham, Katherine;Risi, Susan;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
通讯作者：
Milham MP
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
25
作者：
Dapretto, M;Davies, MS;Iacoboni, M
通讯作者：
Iacoboni, M
影响因子：
25
作者：
Giedd, JN;Blumenthal, J;Rapoport, JL
通讯作者：
Rapoport, JL