Ankle-brachial index and the incidence of cardiovascular events in the Mediterranean low cardiovascular risk population ARTPER cohort.
Ankle-brachial index and the incidence of cardiovascular events in the Mediterranean low cardiovascular risk population ARTPER cohort.
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地中海低心血管风险人群 ARTPER 队列中的踝臂指数和心血管事件发生率。
DOI：
10.1186/1471-2261-13-119
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发表时间：
2013-12-17
影响因子：
2.1
通讯作者：
Vela C
中科院分区：
文献类型：
--
作者：
Alzamora MT;Forés R;Pera G;Torán P;Heras A;Sorribes M;Baena-Diez JM;Urrea M;Alegre J;Viozquez M;Vela C
下肢外周动脉疾病(PAD)是一种非常常见的心血管疾病，尤其是无症状的。在西班牙等冠状动脉风险较低的国家，其患病率开始引起人们的关注。在像西班牙这样的低心血管风险国家，很少有研究分析踝臂指数(ABI)与心血管病死率的关系，在那里，我们观察到缺血性心脏病的发病率显著较低，而心血管危险因素的患病率较高。这项研究的目的是在西班牙49年人群队列(ARTPER)中确定病理性ABI与心血管事件(冠心病、脑血管疾病、腹主动脉症状性动脉瘤、血管手术)和死亡的发生率之间的关系。对来自巴塞罗那28个初级卫生中心的3,786名随机选择的患者进行了基线ABI测量，分布为：ABI<；0.9外周动脉疾病(PAD)，ABI≥1.4动脉钙化(AC)，ABI0.9-1.4健康；并在4年内进行随访。排除既往有血管事件的受试者后，纳入了3307名受试者。ABI异常的受试者年龄较大，男性、吸烟者和糖尿病患者的比例较高。260人出现心血管事件(发病率2,117/100,000人年)，124人死于任何原因(发病率978/100,000人年)。PAD患者发生冠状动脉疾病的风险增加2倍(调整后的危险比(HR) = 为2.0，95%可信区间(CI)为1.3-3.2)，血管手术风险(HR = 5.6，95%CI为2.8-11.5)和死亡率(HR = 为1.8，95%CI为1.4-2.5)。AC使发生脑血管事件的风险增加一倍(HR = 为1.9，95%CI为1.0~3.5)，与缺血性心脏病无关。在低心血管风险的地中海人群中，PAD增加了冠心病和AC脑血管疾病的风险。ABI可能是一种有用的工具，可以在初级卫生保健中发现有风险的患者。
Peripheral arterial disease (PAD) of the lower limbs is a cardiovascular disease highly prevalent particularly in the asymptomatic form. Its prevalence starts to be a concern in low coronary risk countries like Spain. Few studies have analyzed the relationship between ankle-brachial index (ABI) and cardiovascular morbi-mortality in low cardiovascular risk countries like Spain where we observe significant low incidence of ischemic heart diseases together with high prevalence of cardiovascular risk factors. The objective of this study is to determine the relationship between pathological ABI and incidence of cardiovascular events (coronary disease, cerebrovascular disease, symptomatic aneurism of abdominal aorta, vascular surgery) and death in the >49 year population-based cohort in Spain (ARTPER). Baseline ABI was measured in 3,786 randomly selected patients from 28 Primary Health Centers in Barcelona, distributed as: ABI<0.9 peripheral arterial disease (PAD), ABI ≥1.4 arterial calcification (AC), ABI 0.9-1.4 healthy; and followed during 4 years. 3,307 subjects were included after excluding those with previous vascular events. Subjects with abnormal ABI were older with higher proportion of men, smokers and diabetics. 260 people presented cardiovascular events (incidence 2,117/100,000 person-years) and 124 died from any cause (incidence 978/100,000 person-years). PAD had two-fold greater risk of coronary disease (adjusted hazard ratio (HR) = 2.0, 95% confidence interval (CI) 1.3-3.2) and increased risk of vascular surgery (HR = 5.6, 95%CI 2.8-11.5) and mortality (HR = 1.8, 95%CI 1.4-2.5). AC increased twice risk of cerebrovascular events (HR = 1.9, 95%CI 1.0-3.5) with no relationship with ischemic heart disease. PAD increases coronary disease risk and AC cerebrovascular disease risk in low cardiovascular risk Mediterranean population. ABI could be a useful tool to detect patients at risk in Primary Health Care.
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影响因子：
120.7
作者：
Fowkes, F. G. R.;Murray, G. D.;Butcher, I.;Heald, C. L.;Lee, R. J.;Chambless, L. E.;Folsom, A. R.;Hirsch, A. T.;Dramaix, M.;deBacker, G.;Wautrecht, J-C.;Kornitzer, M.;Newman, A. B.;Cushman, M.;Sutton-Tyrrell, K.;Lee, A. J.;Price, J. F.;d'Agostino, R. B.;Murabito, J. M.;Norman, P. E.;Jamrozik, K.;Curb, J. D.;Masaki, K. H.;Rodriquez, B. L.;Dekker, J. M.;Bouter, L. M.;Heine, R. J.;Nijpels, G.;Stehouwer, C. D. A.;Ferrucci, L.;McDermott, M. M.;Stoffers, H. E.;Hooi, J. D.;Knottnerus, J. A.;Ogren, M.;Hedblad, B.;Witteman, J. C.;Breteler, M. M. B.;Hunink, M. G. M.;Hofman, A.;Criqui, M. H.;Langer, R. D.;Fronek, A.;Hiatt, W. R.;Hamman, R.;Resnick, H. E.;Guralnik, J.;McDermott, M. M.
通讯作者：
McDermott, M. M.
DOI：
10.1016/j.ejvs.2008.01.013
发表时间：
2008-06-01
影响因子：
5.7
作者：
Suominen, V.;Rantanen, T.;Salenius, J.
通讯作者：
Salenius, J.
影响因子：
1.6
作者：
Carbayo Herencia, Julio A.;Artigao Rodenas, Luis Miguel;Torres Moreno, Pilar
通讯作者：
Torres Moreno, Pilar
影响因子：
37.8
作者：
Diehm, Curt;Allenberg, Jens Rainer;Trampisch, Hans Joachim
通讯作者：
Trampisch, Hans Joachim
影响因子：
24
作者：
Criqui, Michael H.;McClelland, Robyn L.;McDermott, Mary M.;Allison, Matthew A.;Blumenthal, Roger S.;Aboyans, Victor;Ix, Joachim H.;Burke, Gregory L.;Liu, Kaing;Shea, Steven
通讯作者：
Shea, Steven