Physical activity and endometrial cancer in a population-based case-control study.
Physical activity and endometrial cancer in a population-based case-control study.
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DOI：
10.1007/s10552-010-9689-0
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发表时间：
2011-02
影响因子：
2.3
通讯作者：
Yu, Herbert
中科院分区：
文献类型：
--
作者：
Arem, Hannah;Irwin, Melinda L.;Zhou, Yang;Lu, Lingeng;Risch, Harvey;Yu, Herbert
已发表的关于体力活动、BMI和子宫内膜癌风险的研究结果相互矛盾，许多人没有报告体力活动问卷的可靠性或有效性。我们收集了667例子宫内膜癌患者和662名年龄匹配的对照组的体力活动数据。访谈-管理问卷，收集人口统计和生活方式信息，包括有效的体力活动问卷。我们用非条件Logistic回归分析了中等强度到高强度的运动/娱乐性体力活动(MV-PA)、坐着时间和子宫内膜癌风险之间的关系。与报告每周MV PA代谢当量(MET)小时数为0的女性相比，报告7.5 MET小时/周或以上的女性在调整包括BMI在内的危险因素后，子宫内膜癌风险降低34%(优势比(OR)=0.66，95%可信区间0.50-0.87)。与每天坐不到4小时的妇女相比，那些每天坐着超过8小时的妇女患子宫内膜癌的几率增加了52%(95%可信区间1.07-2.16)。我们创建了体力活动和体重指数的综合衡量标准，发现体重指数为25，活动水平为≥7.5Met h/wk的女性与超重(BMI≥25)和久坐(Met h/wk=0)的参照组相比，患子宫内膜癌的风险降低了73%(OR=0.27，95%CI 0.18-0.39)。我们的数据支持在调整BMI和其他危险因素后，体力活动与子宫内膜癌风险之间的反向独立关联。
Published studies of physical activity, BMI, and endometrial cancer risk show conflicting results and many do not report on reliability or validity of physical activity questionnaires. We collected physical activity data on 667 incident cases of endometrial cancer and 662 age-matched controls. Interview-administered questionnaires, collecting demographic and lifestyle information, including a validated questionnaire for physical activity. We performed unconditional logistic regression to examine the relationship between moderate- to vigorous-intensity sports/recreational physical activity (MV PA), sit time, and endometrial cancer risk. Compared to women reporting 0 metabolic equivalent (MET) hours per week of MV PA, those who reported 7.5 MET h/wk or more had a 34% lower endometrial cancer risk (odds ratio (OR) = 0.66, 95% CI 0.50–0.87) after adjusting for risk factors including BMI. Those women sitting more than 8 h per day had a 52% increased odds (95% CI 1.07–2.16) of endometrial cancer compared to those sitting less than 4 h per day. We created a composite measure of physical activity and BMI and found that women with a BMI<25 and activity levels ≥7.5 MET h/wk had a 73% lower endometrial cancer risk (OR = 0.27, 95% CI 0.18–0.39) compared with the reference group of overweight (BMI ≥25) and sedentary (MET h/wk = 0). Our data support an inverse, independent association between physical activity and endometrial cancer risk after adjusting for BMI and other risk factors.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
2.3
作者：
Conroy, Molly B.;Sattelmair, Jacob R.;Cook, Nancy R.;Manson, JoAnn E.;Buring, Julie E.;Lee, I-Min
通讯作者：
Lee, I-Min
影响因子：
4.2
作者：
Friedenreich, CM;Orenstein, MR
通讯作者：
Orenstein, MR
影响因子：
5
作者：
Littman, AJ;Voigt, LF;Weiss, NS
通讯作者：
Weiss, NS
影响因子：
8.2
作者：
Dunstan, DW;Salmon, J;Shaw, JE
通讯作者：
Shaw, JE