Physical activity, adiposity, and risk of endometrial cancer.
Physical activity, adiposity, and risk of endometrial cancer.
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DOI：
10.1007/s10552-009-9313-3
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发表时间：
2009-09
影响因子：
2.3
通讯作者：
Lee, I-Min
中科院分区：
文献类型：
--
作者：
Conroy, Molly B.;Sattelmair, Jacob R.;Cook, Nancy R.;Manson, JoAnn E.;Buring, Julie E.;Lee, I-Min
我们研究了闲暇时间体育活动和肥胖与子宫内膜癌风险的关系。符合条件的受试者是来自妇女健康研究的32,642名年龄≥45岁的健康美国女性。妇女在调查问卷中报告了1992-1995年基线时的体重、身高和体力活动，以及72个月时的腰围和臀围。在平均8.8年的随访中，264名女性患上了子宫内膜癌，这是通过医疗记录证实的。体重最重的女性（体重指数，BMI≥30 kg/m2）患子宫内膜癌的风险是体重最低的女性（BMI <22.5 kg/m2）的两倍多（多变量校正相对危险度，RR = 2.49[95%可信区间[CI] = 1.73, 3.59]）。在多变量分析中，腰围和腰臀比都不能预测风险。闲暇时间的体育活动和散步也与风险无关。与BMI无关，报告剧烈运动的女性的风险低于没有剧烈运动的女性（多变量调整RR = 0.74[0.56, 0.97]），但没有随着剧烈运动中能量消耗的增加而降低风险的趋势。在检查BMI和身体活动的联合影响时，与运动（≥15 MET-hours/week）、正常体重（BMI <25）、不运动（<15 MET-hours/week）和超重（BMI≥25）的女性相比，风险更高（多变量调整RR = 1.85[1.26, 2.72]），超重和运动的女性也是如此（多变量调整RR = 1.60[1.01, 2.54]），而正常体重、不运动的女性（多变量调整RR = 1.17[0.77, 1.77]）没有更高的风险。这项研究证实BMI是子宫内膜癌风险的一个强有力的预测指标。调整BMI后，中心性肥胖不能独立预测风险；此外，也没有明确的证据表明，这与闲暇时间的体育活动呈负相关。
We examined the associations of leisure-time physical activity and adiposity with endometrial cancer risk. Eligible subjects were 32,642 healthy U.S. women, ≥45 years, from the Women’s Health Study. Women reported on questionnaires their weight, height, and physical activity at baseline (1992–1995), and waist and hip circumference at 72 months. During an average follow-up of 8.8 years, 264 women developed endometrial cancer, confirmed using medical records. The heaviest women (body mass index, BMI ≥30 kg/m2) had more than twice the risk of endometrial cancer as those least heavy (BMI <22.5 kg/m2) (multivariable-adjusted relative risk, RR = 2.49 [95% confidence interval [CI] = 1.73, 3.59]). Neither waist nor waist/hip ratio predicted risk in multivariate analyses. Leisure-time physical activity and walking were also unrelated to risk. Women reporting any vigorous activity had lower risk than those reporting none (multivariable-adjusted RR = 0.74 [0.56, 0.97]) independent of BMI, but there was no trend of declining risk with increasing energy expended in such activities. In examining the joint effects of BMI and physical activity, compared with active (≥15 MET-hours/week), normal weight (BMI <25) women, those who were both inactive (<15 MET-hours/week) and overweight (BMI ≥25) had higher risk (multivariable-adjusted RR = 1.85 [1.26, 2.72]), as did women who were overweight and active (multivariable-adjusted RR = 1.60 [1.01, 2.54]), whereas normal weight, inactive women (multivariable-adjusted RR = 1.17 [0.77, 1.77]) did not. This study confirms BMI as a strong predictor of endometrial cancer risk. Central adiposity did not independently predict risk after adjustment for BMI; there also was no clear evidence of an inverse relation with leisure-time physical activity.
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影响因子：
120.7
作者：
Cook, NR;Lee, IM;Buring, JE
通讯作者：
Buring, JE
影响因子：
2.3
作者：
Colbert, LH;Lacey, JV;Albanes, D
通讯作者：
Albanes, D
影响因子：
6.4
作者：
Patel, Alpa V.;Feigelson, Heather Spencer;Calle, Eugenia E.
通讯作者：
Calle, Eugenia E.
DOI：
10.1249/01.mss.0000084622.39122.0c
发表时间：
2003-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Eyler, AA;Brownson, RC;Housemann, RA
通讯作者：
Housemann, RA
DOI：
10.1089/152460900318911
发表时间：
2000-01-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Rexrode, KM;Lee, IM;Buring, JE
通讯作者：
Buring, JE