Smaller visual arrays are harder to integrate in schizophrenia: Evidence for impaired lateral connections in early vision.
Smaller visual arrays are harder to integrate in schizophrenia: Evidence for impaired lateral connections in early vision.
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DOI：
10.1016/j.psychres.2019.112636
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发表时间：
2019-12
影响因子：
11.3
通讯作者：
Silverstein SM
中科院分区：
文献类型：
--
作者：
Keane BP;Paterno D;Crespo LP;Kastner S;Silverstein SM
早期视觉中的长距离水平连接巩固了一个被充分研究的“共线促进”效应，其中中央低对比度目标在两侧有共线元素时变得更容易检测。精神分裂症患者的共线易化较弱。横向联系可能是原因吗？为了考虑这种可能性，我们让38名精神分裂症患者和49名匹配良好的健康对照者判断中央低对比度元素的存在，两侧是共线或正交的高对比度元素。按比例缩放展示（靶+侧翼）的大小以产生较低和较高的SF条件（分别为4和10个循环/度）。较大的刺激阵列偏向于高阶视觉区域的反馈连接处理;较小的阵列偏向于横向连接处理。在较高而非较低的SF时，患者相对于对照组易化受损。结合数据从过去的研究“轮廓整合”（其中受试者必须检测链的共圆元素），我们发现相关的整合和促进性能在较高的SF和类似的影响，空间缩放整个SF，这表明一个共同的机制。在一项探索性分析中，对比度阈值较差（无促进作用）与更多的病前功能障碍密切相关。在精神分裂症中，元件间的填充在较小的空间尺度上可能是因为它增加了对早期视觉中受损的横向连接的依赖。
Long-range horizontal connections in early vision undergird a well-studied “collinear facilitation” effect, wherein a central low-contrast target becomes more detectable when flanked by collinear elements. Collinear facilitation is weaker in schizophrenia. Might lateral connections be responsible? To consider the possibility, we had 38 schizophrenia patients and 49 well-matched healthy controls judge the presence of a central low-contrast element flanked by collinear or orthogonal high-contrast elements. The display (target + flankers) was scaled in size to produce a lower and higher SF condition (4 and 10 cycles/deg, respectively). Larger stimulus arrays bias processing towards feedback connections from higher-order visual areas; smaller arrays bias processing toward lateral connections. Patients had impaired facilitation relative to controls at higher but not lower SFs. Combining data from a past study on “contour integration” (wherein subjects had to detect chains of co-circular elements), we found correlated integration and facilitation performance at the higher SF and a similar effect of spatial scaling across SF, suggesting a common mechanism. In an exploratory analysis, worse contrast thresholds (without facilitation) correlated strongly with more premorbid dysfunction. In schizophrenia, inter-element filling-in worsens at smaller spatial scales potentially because of its increased reliance on impaired lateral connections in early vision.
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影响因子：
6.6
作者：
Jaeger, J;Berns, SM;Czobor, P
通讯作者：
Czobor, P
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
11.3
作者：
Saracco-Alvarez, Ricardo;Rodriguez-Verdugo, Soledad;Fresan, Ana
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Fresan, Ana
影响因子：
10.6
作者：
Andreasen, Nancy C.;Pressler, Marcus;Nopoulos, Peg;Miller, Del;Ho, Beng-Choon
通讯作者：
Ho, Beng-Choon
DOI：
10.1176/appi.ajp.2013.12111438
发表时间：
2014-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Meier MH;Caspi A;Reichenberg A;Keefe RS;Fisher HL;Harrington H;Houts R;Poulton R;Moffitt TE
通讯作者：
Moffitt TE