Advancing drug discovery and development from active constituents of yinchenhao tang, a famous traditional chinese medicine formula.
Advancing drug discovery and development from active constituents of yinchenhao tang, a famous traditional chinese medicine formula.
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DOI：
10.1155/2013/257909
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhang A;Sun H;Qiu S;Wang X
几千年来，中药配方在保健和疾病控制方面发挥着非常重要的作用。以中医证候理论为指导，将各种中药组合在一起，发挥协同作用。然而，协同作用的精确机制仍然知之甚少。一个例子是著名的中药配方茵陈蒿汤（YCHT），其治疗肝损伤（HI）和黄疸综合征的疗效，最近已被很好地确立为案例研究。并从生物化学、药代动力学和系统生物学等方面对主药协同作用进行了系统分析，探讨了其关键分子机制。我们已经发现，三种组分（6，7-二甲基七叶苷（D）、京尼平苷（G）和大黄酸（R））的组合通过击中多个靶标而比三种单独化合物中的任何一种或两种发挥更稳健的协同效应。它们可以通过激活内在和外在途径来调节分子网络，从而协同地引起增强的治疗效果。本文概述了化学指纹图谱与系统生物学相结合的最新和潜在发展，以促进药物发现，从而更灵活地开发YCHT的靶向联合治疗。
Traditional Chinese medicine (TCM) formula has been playing a very important role in health protection and disease control for thousands of years. Guided by TCM syndrome theories, formula are designed to contain a combination of various kinds of crude drugs that, when combined, will achieve synergistic efficacy. However, the precise mechanism of synergistic action remains poorly understood. One example is a famous TCM formula Yinchenhao Tang (YCHT), whose efficacy in treating hepatic injury (HI) and Jaundice syndrome, has recently been well established as a case study. We also conducted a systematic analysis of synergistic effects of the principal compound using biochemistry, pharmacokinetics and systems biology, to explore the key molecular mechanisms. We had found that the three component (6,7-dimethylesculetin (D), geniposide (G), and rhein (R)) combination exerts a more robust synergistic effect than any one or two of the three individual compounds by hitting multiple targets. They can regulate molecular networks through activating both intrinsic and extrinsic pathways to synergistically cause intensified therapeutic effects. This paper provides an overview of the recent and potential developments of chemical fingerprinting coupled with systems biology advancing drug discovery towards more agile development of targeted combination therapies for the YCHT.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7
作者：
Wang, Xijun;Zhang, Aihua;Meng, Xiangcai
通讯作者：
Meng, Xiangcai
影响因子：
7.9
作者：
Lv, H.;Sun, H.;Cao, H.
通讯作者：
Cao, H.
基于指纹图谱和五种活性成分同时测定的茵陈蒿汤提取物质量评价
影响因子：
3.1
作者：
Wang, Xijun;Lv, Haitao;Bi, Kaishun
通讯作者：
Bi, Kaishun
影响因子：
4.4
作者：
van der Greef, J.;Martin, S.;McBurney, R. N.
通讯作者：
McBurney, R. N.